Ecto-nox disulfide-thiol exchanger 1

ENOX1
Identifiers
Aliases	ENOX1, CNOX, PIG38, bA64J21.1, cCNOX, ecto-NOX disulfide-thiol exchanger 1
External IDs	OMIM: 610914 MGI: 2444896 HomoloGene: 56793 GeneCards: ENOX1
Gene location (Human) Chr. Chromosome 13 (human) Band 13q14.11 Start 43,213,130 bp End 43,786,972 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 D3 Start 77,156,763 bp End 77,721,760 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm ganglionic eminence secondary oocyte middle temporal gyrus Brodmann area 23 prefrontal cortex superior frontal gyrus dorsolateral prefrontal cortex postcentral gyrus nucleus accumbens Top expressed in secondary oocyte ganglionic eminence trigeminal ganglion medial ganglionic eminence piriform cortex spermatocyte neural tube hippocampus proper pontine nuclei superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity protein binding nucleic acid binding Cellular component extracellular region membrane extracellular space plasma membrane external side of plasma membrane Biological process rhythmic process ultradian rhythm Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55068 239188 Ensembl ENSG00000120658 ENSMUSG00000022012 UniProt Q8TC92 Q8BHR2 RefSeq (mRNA) NM_001127615 NM_001242863 NM_017993 NM_001347963 NM_001347964 NM_001347965 NM_001347966 NM_001347967 NM_001347968 NM_001347969 NM_001347970 NM_001347971 NM_001253759 NM_172813 RefSeq (protein) NP_001121087 NP_001229792 NP_060463 NP_001334892 NP_001334893 NP_001334894 NP_001334895 NP_001334896 NP_001334897 NP_001334898 NP_001334899 NP_001334900 NP_001240688 NP_766401 Location (UCSC) Chr 13: 43.21 – 43.79 Mb Chr 14: 77.16 – 77.72 Mb PubMed search
Wikidata
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Ecto-NOX disulfide-thiol exchanger 1 is a protein that in humans is encoded by the ENOX1 gene.

Function

Electron transport pathways are generally associated with mitochondrial membranes, but non-mitochondrial pathways are also biologically significant. Plasma membrane electron transport pathways are involved in functions as diverse as cellular defense, intracellular redox homeostasis, and control of cell growth and survival. Members of the ecto-NOX family, such as CNOX, or ENOX1, are involved in plasma membrane transport pathways. These enzymes exhibit both a hydroquinone (NADH) oxidase activity and a protein disulfide-thiol interchange activity in series, with each activity cycling every 22 to 26 minutes (Scarlett et al., 2005 [PubMed 15882838]).

See also

Ecto-nox disulfide-thiol exchanger 2

Further reading

• Jiang Z, Gorenstein NM, Morré DM, Morré DJ (2008). "Molecular cloning and characterization of a candidate human growth-related and time-keeping constitutive cell surface hydroquinone (NADH) oxidase". Biochemistry. 47 (52): 14028–38. doi:10.1021/bi801073p. PMID 19055324.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Landouré G, Knight MA, Stanescu H, Taye AA, Shi Y, Diallo O, Johnson JO, Hernandez D, Traynor BJ, Biesecker LG, Elkahloun A, Rinaldi C, Vincent A, Willcox N, Kleta R, Fischbeck KH, Burnett BG (2012). "A candidate gene for autoimmune myasthenia gravis". Neurology. 79 (4): 342–7. doi:10.1212/WNL.0b013e318260cbd0. PMC 3400092. PMID 22744667.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.