Jump to content

Elongation factor for RNA polymerase II 2

From Wikipedia, the free encyclopedia
ELL2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesELL2, elongation factor for RNA polymerase II 2, MRCCAT1
External IDsOMIM: 601874; MGI: 2183438; HomoloGene: 8094; GeneCards: ELL2; OMA:ELL2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012081

NM_138953

RefSeq (protein)

NP_036213

NP_620403

Location (UCSC)Chr 5: 95.89 – 95.96 MbChr 13: 75.85 – 75.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Elongation factor for RNA polymerase II 2 is a protein that in humans is encoded by the ELL2 gene. [5]

The encoded protein is a component of the superelongation complex (SEC) and drives immunoglobulin synthesis in plasma cells. Sequence variation in ELL2 has been associated with multiple myeloma and altered immunoglobulin levels.

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118985Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001542Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Elongation factor for RNA polymerase II 2". Retrieved 2018-08-24.

Further reading

[edit]