Enocitabine
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AHFS/Drugs.com | International Drug Names |
Routes of administration | IV |
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Formula | C31H55N3O6 |
Molar mass | 565.796 g·mol−1 |
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Enocitabine (INN, marketed under the brand name Sunrabin) is a nucleoside analog used as chemotherapy.
Sunrabin contains the emulsifier HCO-60, which can cause allergic reactions.[1]
Synthesis[edit]
- cytarabine [147-94-4] (1)
- Palmitic anhydride [623-65-4] (2)
- cytidine [65-46-3] (4)
- N-Hexadecanoylcytidine [60107-19-9] (5)
References[edit]
- ^ Tatetsu H, Asou N, Nakamura M, et al. (July 2003). "[Allergic reaction against an emulsifier, HCO-60, contained in multamin and enocitabine]". Rinsho Ketsueki (in Japanese). 44 (7): 471–3. PMID 12931567.
- ^ Cabanillas, F.; Castaer, J.; Palmitoyl/Staroyl Ara-C. Drugs Fut 1980, 5, 12, 617.
- ^ Akiyama, M., Ohishi, J., Shirai, T., Akashi, K., Yoshida, K.-I., Nishikido, J., Hayashi, H., Usubuchi, Y., Nishimura, D., Itoh, H., Shibuya, C., Ishida, T. (1978). "The synthesis of new derivatives of 1-.BETA.-D-arabinofuranosylcytosine". Chemical and Pharmaceutical Bulletin. 26 (3): 981–984. doi:10.1248/cpb.26.981.
- ^ Kageyasu Akashi, et al. DE2426304 (1988 to Asahi Chemical Industry Co Ltd).
- (in Japanese) Sunrabin[permanent dead link]