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FARSB

From Wikipedia, the free encyclopedia
FARSB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFARSB, FARSLB, FRSB, PheHB, PheRS, HSPC173, phenylalanyl-tRNA synthetase beta subunit, phenylalanyl-tRNA synthetase subunit beta, NEDBLLA, RILDBC, RILDBC1
External IDsOMIM: 609690; MGI: 1346035; HomoloGene: 4160; GeneCards: FARSB; OMA:FARSB - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005687

NM_001278075
NM_011811

RefSeq (protein)

NP_005678

NP_001265004
NP_035941

Location (UCSC)Chr 2: 222.57 – 222.66 MbChr 1: 78.39 – 78.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phenylalanyl-tRNA synthetase beta chain is an enzyme that in humans is encoded by the FARSB gene.[5][6]

This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116120Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026245Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Rodova M, Ankilova V, Safro MG (Apr 1999). "Human phenylalanyl-tRNA synthetase: cloning, characterization of the deduced amino acid sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells". Biochem Biophys Res Commun. 255 (3): 765–73. doi:10.1006/bbrc.1999.0141. PMID 10049785.
  6. ^ a b "Entrez Gene: FARSB phenylalanyl-tRNA synthetase, beta subunit".

Further reading

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