FBXW10

FBXW10
Identifiers
Aliases	FBXW10, Fbw10, HREP, SM25H2, SM2SH2, F-box and WD repeat domain containing 10
External IDs	OMIM: 611679 MGI: 3052463 HomoloGene: 32757 GeneCards: FBXW10
Gene location (Human)
Chr.	Chromosome 17 (human)
End	18,779,349 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	62,768,291 bp
RNA expression pattern
	Top expressed in
	testicle; ; right uterine tube; ; cerebellar hemisphere; ; right lobe of liver; ; gastrocnemius muscle; ; left adrenal gland; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; gallbladder; ; right lung;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; secondary oocyte; ; thymus; ; visual cortex; ; pituitary gland; ; superior frontal gyrus; ; cerebellar cortex; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin-protein transferase activity;
Cellular component	cytosol;
Biological process	protein polyubiquitination; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	10517
	213980
	ENSG00000171931
	ENSMUSG00000090173
	Q5XX13
	Q5SUS0
	NM_001267585; NM_001267586; NM_031456
	NM_001033669; NM_001291441
	NP_001254514; NP_001254515
NP_001028841; NP_001278370; NP_001391704; NP_001391705; NP_001391706;
	NP_001391707
	Wikidata
View/Edit Human	View/Edit Mouse

F-box/WD repeat-containing protein 10 is a protein that in humans is encoded by the FBXW10 gene.^[5]^[6]^[7]

Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004).[supplied by OMIM]^[7] Increased expression of the gene has been associated with laminopathies, and in degradation of chromatin associated proteins such as HP1, ATR kinases (Chaturvedi and ParnaiK, 2010, PMID: 20498703).

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171931 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000090173 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kennerson ML, Nassif NT, Nicholson GA (Dec 1998). "Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat". Genomics. 53 (1): 110–2. doi:10.1006/geno.1998.5453. PMID 9787083.
^ Kennerson ML, Gordon MJ, Blair IP, Nicholson GA (Dec 1995). "Single test for two hereditary neuropathies, CMT1A and HNPP". Clin Chem. 41 (10): 1534–5. doi:10.1093/clinchem/41.10.1534. PMID 7586531.
^ ^a ^b "Entrez Gene: FBXW10 F-box and WD repeat domain containing 10".

Further reading[edit]

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Jin J, Cardozo T, Lovering RC, et al. (2005). "Systematic analysis and nomenclature of mammalian F-box proteins". Genes Dev. 18 (21): 2573–80. doi:10.1101/gad.1255304. PMC 525538. PMID 15520277.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171931 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000090173 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9787083-5] Kennerson ML, Nassif NT, Nicholson GA (Dec 1998). "Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat". Genomics. 53 (1): 110–2. doi:10.1006/geno.1998.5453. PMID 9787083.

[pmid7586531-6] Kennerson ML, Gordon MJ, Blair IP, Nicholson GA (Dec 1995). "Single test for two hereditary neuropathies, CMT1A and HNPP". Clin Chem. 41 (10): 1534–5. doi:10.1093/clinchem/41.10.1534. PMID 7586531.

[entrez-7] "Entrez Gene: FBXW10 F-box and WD repeat domain containing 10".

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