FSTL3

FSTL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KCX, 3B4V, 3SEK
Identifiers
Aliases	FSTL3, FLRG, FSRP, follistatin like 3
External IDs	OMIM: 605343 MGI: 1890391 HomoloGene: 4280 GeneCards: FSTL3
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.3 Start 676,392 bp End 683,392 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 C1 Start 79,613,106 bp End 79,618,464 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery tibial nerve ascending aorta left coronary artery left uterine tube upper lobe of left lung gastric mucosa right adrenal gland right lung canal of the cervix Top expressed in ascending aorta aortic valve belly cord morula lip right lung lobe external carotid artery adrenal gland left lung internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function fibronectin binding activin binding protein binding Cellular component Golgi apparatus secretory granule nucleoplasm extracellular region neuron projection terminus nucleus extracellular space endoplasmic reticulum lumen Biological process male gonad development regulation of transcription, DNA-templated negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway ossification negative regulation of osteoclast differentiation positive regulation of cell-cell adhesion kidney development lung development regulation of transcription by RNA polymerase II adrenal gland development transcription, DNA-templated negative regulation of BMP signaling pathway negative regulation of activin receptor signaling pathway cellular response to metal ion hematopoietic progenitor cell differentiation spermatogenesis positive regulation of transcription by RNA polymerase II post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10272 83554 Ensembl ENSG00000070404 ENSMUSG00000020325 UniProt O95633 Q9EQC7 RefSeq (mRNA) NM_005860 NM_031380 RefSeq (protein) NP_005851 NP_113557 Location (UCSC) Chr 19: 0.68 – 0.68 Mb Chr 10: 79.61 – 79.62 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Follistatin-related protein 3 is a protein that in humans is encoded by the FSTL3 gene.

Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis.

Further reading

• Maguer-Satta V, Rimokh R (2005). "FLRG, member of the follistatin family, a new player in hematopoiesis". Mol. Cell. Endocrinol. 225 (1–2): 109–18. doi:10.1016/j.mce.2004.07.009. PMID 15451575. S2CID 25430198.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Tortoriello DV, Sidis Y, Holtzman DA, et al. (2001). "Human follistatin-related protein: a structural homologue of follistatin with nuclear localization". Endocrinology. 142 (8): 3426–34. doi:10.1210/endo.142.8.8319. PMID 11459787.
• Bartholin L, Maguer-Satta V, Hayette S, et al. (2001). "FLRG, an activin-binding protein, is a new target of TGFbeta transcription activation through Smad proteins". Oncogene. 20 (39): 5409–19. doi:10.1038/sj.onc.1204720. PMID 11571638. S2CID 29503172.
• Bartholin L, Maguer-Satta V, Hayette S, et al. (2002). "Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function". Oncogene. 21 (14): 2227–35. doi:10.1038/sj.onc.1205294. PMID 11948405. S2CID 1065429.
• Hill JJ, Davies MV, Pearson AA, et al. (2002). "The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum". J. Biol. Chem. 277 (43): 40735–41. doi:10.1074/jbc.M206379200. PMID 12194980.
• Liu J, Vänttinen T, Hydén-Granskog C, Voutilainen R (2003). "Regulation of follistatin-related gene (FLRG) expression by protein kinase C and prostaglandin E(2) in cultured granulosa-luteal cells". Mol. Hum. Reprod. 8 (11): 992–7. doi:10.1093/molehr/8.11.992. PMID 12397211.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Maguer-Satta V, Bartholin L, Jeanpierre S, et al. (2003). "Regulation of human erythropoiesis by activin A, BMP2, and BMP4, members of the TGFbeta family". Exp. Cell Res. 282 (2): 110–20. doi:10.1016/S0014-4827(02)00013-7. PMID 12531697.
• Wang HQ, Takebayashi K, Tsuchida K, et al. (2003). "Follistatin-related gene (FLRG) expression in human endometrium: sex steroid hormones regulate the expression of FLRG in cultured human endometrial stromal cells". J. Clin. Endocrinol. Metab. 88 (9): 4432–9. doi:10.1210/jc.2002-021758. PMID 12970321.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Xia Y, Sidis Y, Schneyer A (2004). "Overexpression of follistatin-like 3 in gonads causes defects in gonadal development and function in transgenic mice". Mol. Endocrinol. 18 (4): 979–94. doi:10.1210/me.2003-0364. PMID 14739256.
• Florio P, Ciarmela P, Toti P, et al. (2004). "Human endometrium and decidua express follistatin-related gene (FLRG) mRNA and peptide". Mol. Cell. Endocrinol. 218 (1–2): 129–35. doi:10.1016/j.mce.2003.12.019. PMID 15130517. S2CID 42635058.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Saito S, Sidis Y, Mukherjee A, et al. (2006). "Differential biosynthesis and intracellular transport of follistatin isoforms and follistatin-like-3". Endocrinology. 146 (12): 5052–62. doi:10.1210/en.2005-0833. PMID 16150905.
• Okamoto A, Endo H, Kalionis B, et al. (2006). "IGFBP1 and Follistatin-like 3 genes are significantly up-regulated in expression profiles of the IUGR placenta". Placenta. 27 (2–3): 317–21. doi:10.1016/j.placenta.2004.12.007. PMID 16338475.

External links

• FSTL3 human gene location in the UCSC Genome Browser.
• FSTL3 human gene details in the UCSC Genome Browser.