FUT4
 | This article provides insufficient context for those unfamiliar with the subject. (August 2024) |
| fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | FUT4 | ||||||
| Alt. symbols | CD15, FCT3A, ELFT, SSEA-1, LeX | ||||||
| NCBI gene | 2526 | ||||||
| HGNC | 4015 | ||||||
| OMIM | 104230 | ||||||
| RefSeq | NM_002033 | ||||||
| UniProt | P22083 | ||||||
| Other data | |||||||
| EC number | 2.4.1.152 | ||||||
| Locus | Chr. 11 q21 | ||||||
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Fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific), also known as FUT4, is an enzyme which in humans is encoded by the FUT4 gene.[1][2][3]
Function
[edit]The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15).[4][5]
References
[edit]- ^ Goelz SE, Hession C, Goff D, Griffiths B, Tizard R, Newman B, Chi-Rosso G, Lobb R (December 1990). "ELFT: a gene that directs the expression of an ELAM-1 ligand". Cell. 63 (6): 1349–56. doi:10.1016/0092-8674(90)90430-M. PMID 1702034. S2CID 905332.
- ^ Couillin P, Mollicone R, Grisard MC, Gibaud A, Ravisé N, Feingold J, Oriol R (1991). "Chromosome 11q localization of one of the three expected genes for the human alpha-3-fucosyltransferases, by somatic hybridization". Cytogenet. Cell Genet. 56 (2): 108–11. doi:10.1159/000133061. PMID 1672847.
- ^ Reguigne I, James MR, Richard CW, Mollicone R, Seawright A, Lowe JB, Oriol R, Couillin P (1994). "The gene encoding myeloid alpha-3-fucosyl-transferase (FUT4) is located between D1 1S388 and D11S919 on 11q21". Cytogenet. Cell Genet. 66 (2): 104–6. doi:10.1159/000133677. PMID 8287679.
- ^ "Entrez Gene: FUT4".
- ^ Nakayama F, Nishihara S, Iwasaki H, Kudo T, Okubo R, Kaneko M, Nakamura M, Karube M, Sasaki K, Narimatsu H (May 2001). "CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV". J. Biol. Chem. 276 (19): 16100–6. doi:10.1074/jbc.M007272200. PMID 11278338.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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