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GABPB2

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GABPB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGABPB1, BABPB2, E4TF1, E4TF1-47, E4TF1-53, E4TF1B, GABPB, GABPB2, NRF2B1, NRF2B2, GABPB-1, GA binding protein transcription factor beta subunit 1, GA binding protein transcription factor subunit beta 1
External IDsOMIM: 600610; MGI: 95611; HomoloGene: 7723; GeneCards: GABPB1; OMA:GABPB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 15: 50.28 – 50.36 MbChr 2: 126.47 – 126.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GA-binding protein subunit beta-1 is a protein that in humans is encoded by the GABPB1 gene.[5][6]

This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104064Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027361Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ de la Brousse FC, Birkenmeier EH, King DS, Rowe LB, McKnight SL (Nov 1994). "Molecular and genetic characterization of GABP beta". Genes Dev. 8 (15): 1853–65. doi:10.1101/gad.8.15.1853. PMID 7958862.
  6. ^ a b "Entrez Gene: GABPB2 GA binding protein transcription factor, beta subunit 2".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.