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GAL3ST1

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GAL3ST1
Identifiers
AliasesGAL3ST1, CST, galactose-3-O-sulfotransferase 1
External IDsOMIM: 602300; MGI: 1858277; HomoloGene: 3574; GeneCards: GAL3ST1; OMA:GAL3ST1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001177691
NM_001177703
NM_016922
NM_001382290
NM_001382291

RefSeq (protein)

NP_001171162
NP_001171174
NP_058618
NP_001369219
NP_001369220

Location (UCSC)Chr 22: 30.55 – 30.57 MbChr 11: 3.93 – 3.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Galactosylceramide sulfotransferase is an enzyme that in humans is encoded by the GAL3ST1 gene.[5][6][7]

Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128242Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049721Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sanger Centre, The; Washington University Genome Sequencing Cente, The (Jan 1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  6. ^ Honke K, Tsuda M, Hirahara Y, Ishii A, Makita A, Wada Y (Apr 1997). "Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase". J Biol Chem. 272 (8): 4864–8. doi:10.1074/jbc.272.8.4864. PMID 9030544.
  7. ^ a b "Entrez Gene: GAL3ST1 galactose-3-O-sulfotransferase 1".

Further reading

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