Jump to content

GOLGA3

From Wikipedia, the free encyclopedia

GOLGA3
Identifiers
AliasesGOLGA3, GCP170, MEA-2, golgin A3, Golgin 160
External IDsOMIM: 602581; MGI: 96958; HomoloGene: 4308; GeneCards: GOLGA3; OMA:GOLGA3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001172557
NM_005895

NM_008146
NM_001347389

RefSeq (protein)

NP_001166028
NP_005886

NP_001334318
NP_032172

Location (UCSC)Chr 12: 132.77 – 132.83 MbChr 5: 110.32 – 110.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Golgin subfamily A member 3 is a protein that in humans is encoded by the GOLGA3 gene.[5][6][7]

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis.

This gene encodes a member of the golgin family of proteins which are localized to the Golgi. Its encoded protein has been postulated to play a role in nuclear transport and Golgi apparatus localization. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined.[7]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000090615Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029502Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fritzler MJ, Hamel JC, Ochs RL, Chan EK (Jul 1993). "Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex". J Exp Med. 178 (1): 49–62. doi:10.1084/jem.178.1.49. PMC 2191081. PMID 8315394.
  6. ^ Maag RS, Mancini M, Rosen A, Machamer CE (Jun 2005). "Caspase-resistant Golgin-160 Disrupts Apoptosis Induced by Secretory Pathway Stress and Ligation of Death Receptors". Mol Biol Cell. 16 (6): 3019–27. doi:10.1091/mbc.E04-11-0971. PMC 1142444. PMID 15829563.
  7. ^ a b "Entrez Gene: GOLGA3 golgi autoantigen, golgin subfamily a, 3".

Further reading

[edit]