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Gentamicin 2'-N-acetyltransferase

From Wikipedia, the free encyclopedia
gentamicin 2'-N-acetyltransferase
Identifiers
EC no.2.3.1.59
CAS no.50864-40-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a gentamicin 2'-N-acetyltransferase (EC 2.3.1.59) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + gentamicin C1a CoA + N2'-acetylgentamicin C1a

Thus, the two substrates of this enzyme are acetyl-CoA and gentamicin C1a, whereas its two products are CoA and N2'-acetyl gentamicin C1a.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:gentamicin-C1a N2'-acetyltransferase. Other names in common use include gentamicin acetyltransferase II, gentamicin 2'-N-acetyltransferase, and acetyl-CoA:gentamicin-C1a N2'-acetyltransferase.

References

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  • Benveniste R, Davies J (1973). "Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria". Proc. Natl. Acad. Sci. U.S.A. 70 (8): 2276–80. doi:10.1073/pnas.70.8.2276. PMC 433717. PMID 4209515.