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Glutamate—methylamine ligase

From Wikipedia, the free encyclopedia
Glutamate—methylamine ligase
Identifiers
EC no.6.3.4.12
CAS no.37318-69-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a glutamate—methylamine ligase (EC 6.3.4.12) is an enzyme that catalyzes the chemical reaction

ATP + L-glutamate + methylamine ADP + phosphate + N5-methyl-L-glutamine

The 3 substrates of this enzyme are ATP, L-glutamate, and methylamine, whereas its 3 products are ADP, phosphate, and N5-methyl-L-glutamine.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is L-glutamate:methylamine ligase (ADP-forming). This enzyme is also called gamma-glutamylmethylamide synthetase.

References

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  • Kung HF, Wagner C (1969). "Gamma-glutamylmethylamide. A new intermediate in the metabolism of methylamine". J. Biol. Chem. 244 (15): 4136–40. PMID 5800436.