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Gram domain-containing 2A

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GRAMD2A
Identifiers
AliasesGRAMD2A, GRAMD2, GRAM domain containing 2A
External IDsMGI: 3528937; HomoloGene: 52791; GeneCards: GRAMD2A; OMA:GRAMD2A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001012642

NM_001033498
NM_001357686
NM_001379375
NM_001379376
NM_001379377

RefSeq (protein)

NP_001012660

NP_001028670
NP_001344615
NP_001366304
NP_001366305
NP_001366306

Location (UCSC)Chr 15: 72.16 – 72.2 MbChr 9: 59.59 – 59.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GRAM domain-containing 2A protein (GRAMD2A; formerly GRAMD2) is a protein encoded by the GRAMD2A gene.[5] Like GRAMD2B, the protein consists of a GRAM domain and a transmembrane domain that anchors it to the endoplasmic reticulum.[6][7]

GRAMD2A is a mammalian representative of the yeast lipid transfer proteins anchored at a membrane contact site (LAM) family.[7] It has four paralogs: GRAMD1A, GRAMD1B, GRAMD1C and GRAMD2B. Unlike LAM and its paralogs except GRAMD2B, GRAMD2A lacks a VASt domain.

The protein localizes to sites where membranes from different organelles are in close apposition.[7] There, it tethers the endoplasmic reticulum to the plasma membrane through its GRAM domain binding phosphatidylinositol 4,5-bisphosphate in the plasma membrane at sites enriched for the phospholipid.[7] The protein ensures proper stromal interaction molecule 1 (STIM1) recruitment to these sites of membrane contact as part of the store-operated calcium entry pathway – a component of intracellular calcium homeostasis.[7]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175318Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074259Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "GRAMD2A GRAM domain containing 2A [ Homo sapiens (human) ]". Retrieved March 7, 2020.
  6. ^ "RecName: Full=GRAM domain-containing protein 2A)". Retrieved March 7, 2020.
  7. ^ a b c d e Besprozvannaya M, Dickson E, Li H, Ginburg KS, Bers DM, Auwerx J, Nunnari J (February 2018). "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells". eLife. 22 (7): e31019. doi:10.7554/eLife.31019. PMC 5823543. PMID 29469807.