Jump to content

Grb2 associated binding protein 3

From Wikipedia, the free encyclopedia
GAB3
Identifiers
AliasesGAB3, GRB2 associated binding protein 3
External IDsOMIM: 300482; MGI: 2387324; HomoloGene: 15417; GeneCards: GAB3; OMA:GAB3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001081573
NM_001282283
NM_080612

NM_181584

RefSeq (protein)

NP_001075042
NP_001269212
NP_542179

NP_853615

Location (UCSC)Chr X: 154.68 – 154.75 MbChr X: 74.01 – 74.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GRB2 associated binding protein 3 is a protein that in humans is encoded by the GAB3 gene. [5]

Function

[edit]

This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants.

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160219Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032750Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "GAB3 GRB2 associated binding protein 3 [ Homo sapiens (human) ]". National Center for Biotechnology Information. Retrieved 2019-08-03.

Further reading

[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.