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Guillaume De Bo

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Guillaume De Bo
Guillaume De Bo
Born
Guillaume De Bo

Brussels, Belgium[1]
Alma materUniversity of Louvain (Msc., PhD)
Known forPolymer mechanochemistry
Molecular Machines
AwardsBob Hay Lectureship (2021)
Macro Group UK Young Researchers Medal (2021)
Royal Society University Research Fellowship (2015)[1]
Scientific career
Fieldsmechanochemistry[2]
InstitutionsUniversity of Manchester
Thesis Synthesis of angular triquinanes  (2009)
Doctoral advisorProf. István E. Markó
Websitewww.deboresearchgroup.com

Guillaume De Bo is a Professor and a Royal Society University Research Fellow in the Department of Chemistry at the University of Manchester.[3] His research is in the field of polymer mechanochemistry, where he investigates the chemistry of molecules under tension for application in synthetic chemistry, materials and mechanosensors.[2][3]

Education

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Guillaume completed his Master of Science degree at University of Louvain in 2004 where he finished his final year project with Prof. István E. Markó on the development of platinum-based catalysts for the hydrosilylation of alkynes.[4][5] He continued to complete his PhD with Prof. István E. Markó on the synthesis of angular triquinanes at the same university and successfully completed it in 2009.[4][5]

Research and career

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Guillaume completed his postdoctoral research with Prof. Jean-François Gohy and Prof. Charles-André Fustin at University of Louvain where he worked on the assembly of mechanically-linked block copolymers.[4] In 2011, he joined Prof. David Leigh's research group at The University of Edinburgh to work on the development of molecular machines.[4][6] He then joined the University of Manchester after obtaining a Royal Society University Research Fellowship in 2016.[6]

Guillaume's research is in the field of polymer mechanochemistry, where he investigates the chemistry of molecules under tension for application in synthetic chemistry, materials and mechanosensors.[2][3] He is also a committee member of the Royal Society of Chemistry Macrocyclic and Supramolecular Chemistry Group, and worked as the secretary of the Recent Appointees in Polymer Science Committee from 2014 - 2017.[7][8] He was a guest editor in a Supramolecular Chemistry Special Issue on Emerging Supramolecular Chemistry in the UK (2017 - 2018) and worked as the next - generation adviser for Chem (cell press) during 2016 - 2019.[6][9]

Notable work

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In 2020, Guillaume showed that the dissociation of a mechanophore built around an N-heterocyclic carbene precursor proceeds with the rupture of a C–C bond through concomitant heterolytic, concerted and homolytic pathways using 1H- and 19F-nuclear magnetic resonance spectroscopy in combination with deuterium labelling.[10] Normally, a chemical reaction occurs via a radical, concerted or ionic mechanism and transformations such as this where all these mechanisms are involved is extremely rare. The research discovered how molecular tuning influences mechanism which could be used in self-healing polymers or in plastics that break down upon mechanical activation.[11] In the same year, Guillaume showed how the ability of the two rings in [2]catenane to rotate alone each other enables [2]catenane to be used as a mechanical protecting group via the diversion of technical forces away from a mechanically active functional group embedded in one of its rings. This approach showed a new way to control the mechanical activity of a mechanophore.[12][13]

Awards, honours and nominations

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Major Publications

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  • Chen, Lei; Nixon, Robert; De Bo, Guillaume (2024). "Force-controlled release of small molecules with a rotaxane actuator". Nature. 628: 320–325. doi:10.1038/s41586-024-07154-0. PMC 11006608.
  • Nixon, Robert; De Bo, Guillaume (2021). "Isotope Effect in the Activation of a Mechanophore". J. Am. Chem. Soc. 143: 3033–3036. doi:10.1021/jacs.0c11259.

References

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  1. ^ a b c Royal Society of Chemistry. "Dr Guillaume De Bo (Profile)". Retrieved 28 September 2020.
  2. ^ a b c "Dr Guillaume De Bo (Google Scholar)". Retrieved 28 September 2020.
  3. ^ a b c University of Manchester. "Dr Guillaume De Bo(Research)". Retrieved 28 September 2020.
  4. ^ a b c d University of Manchester. "Dr Guillaume De Bo(Overview)". Retrieved 28 September 2020.
  5. ^ a b "Research Gate:Dr Guillaume De Bo". Retrieved 28 September 2020.
  6. ^ a b c "About Guillaume De Bo". Retrieved 28 September 2020.
  7. ^ Royal Society of Chemistry. "Macrocyclic and Supramolecular Chemistry Group". Retrieved 28 September 2020.
  8. ^ Polymer Science. "RAPS". Retrieved 28 September 2020.
  9. ^ De Bo, Guillaume; Serpell, Christopher J.; Kitchen, Jonathan A. (2017). "Emerging investigators in the UK – editorial". Supramolecular Chemistry. 30 (9): 731. doi:10.1080/10610278.2018.1475606. S2CID 104741465.Free access icon
  10. ^ De Bo, Guillaume; Nixon, Robert (2020). "Three concomitant C–C dissociation pathways during the mechanical activation of an N-heterocyclic carbene precursor". Nature Chemistry. 12 (9): 826–831. Bibcode:2020NatCh..12..826N. doi:10.1038/s41557-020-0509-1. PMID 32690898. S2CID 220656588. Closed access icon
  11. ^ Gomollon-Bel, fernando (3 August 2020). "Triple mechanochemistry mechanism might be a first for organic chemistry". Retrieved 28 September 2020.Closed access icon
  12. ^ De Bo, Guillaume; Zhang, Min (2020). "A Catenane as a Mechanical Protecting Group". J. Am. Chem. Soc. 142 (11): 5029–5033. doi:10.1021/jacs.0c01757. PMID 32131588.
  13. ^ Kramer, Katrina (24 March 2020). "Mechanical protecting group shields molecules from stress and strain". Retrieved 28 September 2020.
  14. ^ "Macrocyclic and Supramolecular Chemistry Group Awards". Royal Society of Chemistry. Retrieved 2022-02-22.
  15. ^ "Past Award Winners". Macro Group UK. 2016-04-20. Archived from the original on 2022-02-22. Retrieved 2022-02-22.
  16. ^ Chemistry PASS Scheme, University of Manchester. "ChemStudent's Awards 2020 Nominees". Retrieved 28 September 2020.
  17. ^ Thieme Chemistry. "Thieme Chemistry Journal Award winners (2020)". Retrieved 28 September 2020.