Jump to content

HIF-1 alpha IRES

From Wikipedia, the free encyclopedia
HIF-1 alpha IRES
Predicted secondary structure and sequence conservation of IRES_HIF1
Identifiers
SymbolIRES_HIF1
RfamRF00449
Other data
RNA typeCis-reg; IRES
Domain(s)Eukaryota
GOGO:0043022
SOSO:0000243
PDB structuresPDBe

The HIF-1α internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of HIF-1α that allows cap-independent translation. The HIF-1α internal ribosome entry site (IRES) allows translation to be maintained under hypoxic cell conditions that inhibit cap-dependent translation [1]. The hypoxia-inducible factor-1α protein (HIF-1α) is a subunit of the HIF-1 transcription factor, which induces transcription of several genes involved in the cellular response to hypoxia.

References

[edit]

Further reading

[edit]
  • Lang KJ, Kappel A, Goodall GJ (May 2002). "Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia". Molecular Biology of the Cell. 13 (5): 1792–1801. doi:10.1091/mbc.02-02-0017. PMC 111144. PMID 12006670.
[edit]