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HIST1H2AE

From Wikipedia, the free encyclopedia
H2AC8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesH2AC8, H2A.1, H2A.2, H2A/a, H2AFA, histone cluster 1, H2ae, histone cluster 1 H2A family member e, HIST1H2AE, H2A clustered histone 8, H2AC4
External IDsOMIM: 602786; MGI: 2448457; HomoloGene: 135791; GeneCards: H2AC8; OMA:H2AC8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021052

NM_178182

RefSeq (protein)

NP_003504

Location (UCSC)Chr 6: 26.22 – 26.22 MbChr 13: 21.9 – 21.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histone H2A type 1-B/E is a protein that in humans is encoded by the HIST1H2AE gene.[5][6][7][8]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4).

The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000277075Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071516Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
  6. ^ Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D (Nov 1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes". Genomics. 10 (4): 940–8. doi:10.1016/0888-7543(91)90183-F. PMID 1916825.
  7. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  8. ^ a b "Entrez Gene: HIST1H2AE histone cluster 1, H2ae".

Further reading

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