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HMA domain

From Wikipedia, the free encyclopedia
Heavy-metal-associated domain
solution structure of the n-terminal domain of znta in the zn(ii)-form
Identifiers
SymbolHMA
PfamPF00403
InterProIPR006121
PROSITEPDOC00804
SCOP22hqi / SCOPe / SUPFAM
TCDB9.A.2
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

In molecular biology, the HMA domain (heavy-metal-associated domain) is a conserved protein domain found in a number of heavy metal transport or detoxification proteins.[1]

Proteins that transport heavy metals in micro-organisms and mammals share similarities in their sequences and structures. These proteins provide an important focus for research, some being involved in bacterial resistance to toxic metals, such as lead and cadmium, while others are involved in inherited human syndromes, such as Wilson's and Menke's diseases.[1]

The HMA domain, contains two conserved cysteines that are probably involved in metal binding. The fourth HMA domain of the Menke's copper transporting ATPase shows a well-defined structure comprising a four-stranded antiparallel beta-sheet and two alpha helices packed in an alpha-beta sandwich fold.[2] This fold is common to other domains and is classified as "ferredoxin-like".

References

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  1. ^ a b Bull PC, Cox DW (July 1994). "Wilson disease and Menkes disease: new handles on heavy-metal transport". Trends Genet. 10 (7): 246–52. doi:10.1016/0168-9525(94)90172-4. PMID 8091505.
  2. ^ Gitschier J, Moffat B, Reilly D, Wood WI, Fairbrother WJ (January 1998). "Solution structure of the fourth metal-binding domain from the Menkes copper-transporting ATPase". Nat. Struct. Biol. 5 (1): 47–54. doi:10.1038/nsb0198-47. PMID 9437429. S2CID 172550.
This article incorporates text from the public domain Pfam and InterPro: IPR006121