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HMOX2

From Wikipedia, the free encyclopedia
HMOX2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHMOX2, HO-2, heme oxygenase 2
External IDsOMIM: 141251; MGI: 109373; HomoloGene: 1611; GeneCards: HMOX2; OMA:HMOX2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001136066
NM_010443
NM_001357050
NM_001378999

RefSeq (protein)

NP_001129538
NP_034573
NP_001343979
NP_001365928

Location (UCSC)Chr 16: 4.47 – 4.51 MbChr 16: 4.54 – 4.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Heme oxygenase 2 is an enzyme that in humans is encoded by the HMOX2 gene.[5][6]

Function

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Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 (this enzyme) belong to the heme oxygenase family.[6]

References

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  1. ^ a b c ENSG00000103415 GRCh38: Ensembl release 89: ENSG00000277424, ENSG00000103415Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004070Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McCoubrey WK, Ewing JF, Maines MD (Jun 1992). "Human heme oxygenase-2: characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal". Arch Biochem Biophys. 295 (1): 13–20. doi:10.1016/0003-9861(92)90481-B. PMID 1575508.
  6. ^ a b "Entrez Gene: HMOX2 heme oxygenase (decycling) 2".

Further reading

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