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HS2ST1

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HS2ST1
Identifiers
AliasesHS2ST1, dJ604K5.2, heparan sulfate 2-O-sulfotransferase 1, NFSRA
External IDsOMIM: 604844; MGI: 1346049; HomoloGene: 8025; GeneCards: HS2ST1; OMA:HS2ST1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012262
NM_001134492

NM_011828
NM_001355234

RefSeq (protein)

NP_001127964
NP_036394

NP_035958
NP_001342163

Location (UCSC)Chr 1: 86.91 – 87.11 MbChr 3: 144.14 – 144.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Heparan sulfate 2-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS2ST1 gene.[5][6]

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes heparan sulfate 2-O-sulfotransferase, a member of the heparan sulfate biosynthetic enzyme family. This family member transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate.

The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153936Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040151Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (Feb 1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
  6. ^ a b "Entrez Gene: HS2ST1 heparan sulfate 2-O-sulfotransferase 1".

Further reading

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