HTH-XRE RNA motif
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| HTH-XRE | |
|---|---|
 Consensus secondary structure and sequence conservation of HTH-XRE RNA | |
| Identifiers | |
| Symbol | HTH-XRE |
| Rfam | RF02923 |
| Other data | |
| RNA type | Cis-reg |
| SO | SO:0005836 |
| PDB structures | PDBe |
The HTH-XRE RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] HTH-XRE motifs are found in Clostridiales.
HTH-XRE RNAs are often found upstream of genes encoding proteins with the XRE-like helix-turn-helix protein domain. However, in many cases, HTH-XRE RNAs are not upstream of a protein-coding gene. Additionally, genes encoding XRE-like domains are extremely common in bacteria, so it is possible that the association between this protein domain and the HTH-XRE RNA arises purely by coincidence. Overall, it is ambiguous whether HTH-XRE RNAs function as cis-regulatory elements or whether they operate in trans as small RNAs.
References
[edit]- ^ Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR (October 2017). "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. doi:10.1093/nar/gkx699. PMC 5737381. PMID 28977401.