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Histone-arginine N-methyltransferase

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Histone-arginine N-methyltransferase
Identifiers
EC no.2.1.1.125
CAS no.445295-80-7
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IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
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Histone-arginine N-methyltransferase (EC 2.1.1.125, histone protein methylase I, nuclear protein (histone) N-methyltransferase, protein methylase I, S-adenosyl-L-methionine:histone-arginine omega-N-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:histone-arginine Nomega-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + histone-arginine S-adenosyl-L-homocysteine + histone-Nomega-methyl-arginine

The enzyme forms the Nomega-monomethyl- and Nomega,Nomega'-dimethyl.

References

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  1. ^ Rajpurohit R, Lee SO, Park JO, Paik WK, Kim S (January 1994). "Enzymatic methylation of recombinant heterogeneous nuclear RNP protein A1. Dual substrate specificity for S-adenosylmethionine:histone-arginine N-methyltransferase". The Journal of Biological Chemistry. 269 (2): 1075–82. PMID 8288564.
  2. ^ Rawal N, Rajpurohit R, Paik WK, Kim S (June 1994). "Purification and characterization of S-adenosylmethionine-protein-arginine N-methyltransferase from rat liver". The Biochemical Journal. 300 ( Pt 2) (Pt 2): 483–9. doi:10.1042/bj3000483. PMC 1138188. PMID 8002954.
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