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Hydroperoxide dehydratase

From Wikipedia, the free encyclopedia
hydroperoxide dehydratase
Identifiers
EC no.4.2.1.92
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme hydroperoxide dehydratase (EC 4.2.1.92) catalyzes the chemical reaction

(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate (9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate + H2O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]. Other names in common use include hydroperoxide isomerase, linoleate hydroperoxide isomerase, linoleic acid hydroperoxide isomerase, HPI, (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate, and 12,13-hydro-lyase.

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1U5U.

References

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  • Esselman WJ, Clagett CO (1974). "Products of linoleic hydroperoxide-decomposing enzyme of alfalfa seed". J. Lipid Res. 15 (2): 173–8. doi:10.1016/S0022-2275(20)36821-8. PMID 4208994.
  • Hamberg M (1987). "Mechanism of corn hydroperoxide isomerase - detection of 12,13(S)-oxido-9(Z),11-octadecadienoic acid". Biochim. Biophys. Acta. 920: 76–84. doi:10.1016/0005-2760(87)90313-4.
  • Hamberg M (1988). "Biosynthesis of 12-oxo-10,15(Z)-phytodienoic acid: identification of an allene oxide cyclase". Biochem. Biophys. Res. Commun. 156 (1): 543–50. doi:10.1016/S0006-291X(88)80876-3. PMID 3178850.