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IL1RAPL1

From Wikipedia, the free encyclopedia
IL1RAPL1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL1RAPL1, IL1R8, IL1RAPL, MRX10, MRX21, MRX34, OPHN4, TIGIRR-2, interleukin 1 receptor accessory protein like 1, IL-1RAPL-1, IL-1-RAPL-1, IL1RAPL-1
External IDsOMIM: 300206; MGI: 2687319; HomoloGene: 8609; GeneCards: IL1RAPL1; OMA:IL1RAPL1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014271

NM_001160403

RefSeq (protein)

NP_055086

n/a

Location (UCSC)Chr X: 28.59 – 29.96 MbChr X: 85.78 – 87.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

X-linked interleukin-1 receptor accessory protein-like 1, also known as IL-1R9, is a protein that in humans is encoded by the IL1RAPL1 gene.[5][6][7] IL1RAPL1 is composed of 11 exons, about 1.37 Mb total.[8]

Function

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The protein encoded by this gene, IL-1R9, is a member of the interleukin-1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). [7]

Clinical significance

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This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169306Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052372Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Carrie A, Jun L, Bienvenu T, Vinet MC, McDonell N, Couvert P, Zemni R, Cardona A, Van Buggenhout G, Frints S, Hamel B, Moraine C, Ropers HH, Strom T, Howell GR, Whittaker A, Ross MT, Kahn A, Fryns JP, Beldjord C, Marynen P, Chelly J (Sep 1999). "A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation". Nat Genet. 23 (1): 25–31. doi:10.1038/12623. PMID 10471494. S2CID 38236297.
  6. ^ Jin H, Gardner RJ, Viswesvaraiah R, Muntoni F, Roberts RG (May 2000). "Two novel members of the interleukin-1 receptor gene family, one deleted in Xp22.1-Xp21.3 mental retardation". Eur J Hum Genet. 8 (2): 87–94. doi:10.1038/sj.ejhg.5200415. PMID 10757639. S2CID 22262168.
  7. ^ a b c "Entrez Gene: IL1RAPL1 interleukin 1 receptor accessory protein-like 1".
  8. ^ "OMIM Entry - * 300206 - INTERLEUKIN 1 RECEPTOR ACCESSORY PROTEIN-LIKE 1; IL1RAPL1". www.omim.org. Retrieved 2020-12-05.

Further reading

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