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Jay Tischfield

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Jay Tischfield, August 2008

Jay Tischfield (born June 15, 1946) is Duncan and Nancy MacMillan Distinguished Professor and the Founding Chair (1998 - 2010) of the Department of Genetics at Rutgers University.[1] He is Founding Director of the Rutgers Human Genetics Institute of New Jersey (2005 - 2020).

Professor Tischfield is a diplomate of the American Board of Medical Genetics in PhD Medical Genetics (1987 - ) and Clinical Molecular Genetics (1993 - 2019). He is a Founding Fellow of the American College of Medical Genetics.

He was the CEO and Scientific Director (2005 - 2020) of RUCDR Infinite Biologics®[2] (formerly the Rutgers University Cell & DNA Repository). It was the largest university-based repository in the world collecting, processing and performing genomic assays on human samples.[3] RUCDR was sold for $44.4 millilion in 2020, forming IBX which does business under the name Sampled. Tischfield has six U.S patents.[4]

Education

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Professor Tischfield obtained his bachelor's degree in biology in 1967 at the City University of New York, Brooklyn College. He received a M.Phil degree in biology from Yale University in 1969, and a Ph.D. in 1973.

Major Professional Appointments

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Duncan and Nancy MacMillan Disinguished Professor, Department of Genetics, Rutgers University Piscataway, New Jersey (1998 - )

Founding Chair, Department of Genetics, Rutgers University, Piscataway, New Jersey (1998 - 2010)

Professor, Departments of Pediatrics and Psychiatry, Robert Wood Johnson Medical School, Piscataway, New Jersey (1999 - 2013)

Adjunct (Volunteer) Professor, Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Cincinnati, Ohio (1989 - 2008)

Professor and Director, Division of Molecular Genetics, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana (1987-1998)

Associate Professor and Professor, Departments of Anatomy, Cell and Molecular Biology, Pediatrics, and Graduate Studies, Medical College of Georgia, Augusta, Georgia (1978-1987)

Assistant Professor of Pediatrics in Biology, Department of Pediatrics, Case Western Reserve University Cleveland, Ohio (1974-1978)

Postdoctoral Fellow (NIH) (with Charles J. Epstein) Departments of Pediatrics and Biochemistry University of California San Francisco, California (1972-1973)

Major Research

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At Yale, Tischfield was part of the Frank Ruddle research group that was among the first to map human genes to chromosomes. He established cultures of mouse-human somatic cell hybrids to determine which genes are located on which chromosomes. He mapped many genes, among them the gene for indophenol oxidase in mammals.[5] Later, researchers from Duke University identified this gene as coding for the enzyme superoxide dismutase,[6] which is increased in Down syndrome[7] and mutated in some cases of amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease).

At Indiana University School of Medicine (1987 - 1998) Tischfield's research focused on loss of heterozygosity, a side effect of DNA-repair and recombination. Through this mechanism, expression of tumor suppressor genes can be lost, leading to cancer.[8][9] Also, his group discovered and functionally characterized a family of genes encoding a family of phospholipase A genes important in inflammation and inflammatory diseases.[10]

Tischfield’s research group uses population studies to find genes that are involved in diseases, frequently using cell or DNA samples from the RUCDR Infinite Biologics. In the past, the RUCDR contributed samples to his research projects concerning the genetic causes of a type of muscular dystrophy,[11] alcoholism,[12] autism,[13] Tourette disorder,[14] and others.

Professor Tischfield’s research at Rutgers University focuses on the genetic basis of complex diseases that are caused by many genes, frequently in combination, and often triggered by environmental causes. Tischfield’s lab investigates Tourette disorder, alcohol addiction and dihydroxyadenine urolithiasis and cystinuria, kidney diseases characterized by severe kidney stones. The laboratory has developed knockout mouse models for both kidney stone diseases and is developing therapies.[15] He has developed genetically accurate mouse models of Tourette disorder through gene editing.[16]

Most recently, Tischfield's collaborative research has centered on the genetic and neurological bases of Tourette disorder.[17][18] Behavioral and neuroscience studies of mouse models were done in collaboration with Max Tischfield [19] with the hope of using these mice for drug development. Tischfield has authored or co-authored over 340 peer-reviewed publications.[20]

Professor Tischfield's role has extended from science to University and New Jersey State politics and in 2011 NJBIZ listed Tischfield as being the 85th most powerful person in New Jersey business, mainly because of his political influence.[21]

Personal

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Tischfield is married to Donna Mitchell Tischfield and has three sons, all involved in biomedical research. The oldest, Max (PhD, neuroscience) is Rutgers Neuroscience faculty, his middle son, Samuel (PhD, computational biology) is a Senior Computational Biologist at Memorial Sloan Kettering Cancer Center, and the youngest, David, (MD and PhD, radiology and neuroscience) is Assistant Professor at UPenn [22][23][24] Jay Tischfield is also a big fan of Donald Duck.[25] He took up scuba diving and became certified in 1963, at age 17, and as of 2020 he had been diving in Hawaii, throughout the caribbean and in Indonesia.[25] He began SCCA auto racing in 1986 and currently drives a 2021 Corvette.

Awards

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  • New Jersey Heart of BioNJ Award to Rutgers RUCDR, for first saliva-based COVID-19 test (2022)
  • Tourette Syndrome Lifetime Achievement Award, New Jersey Center for Tourette Syndrome (2022)
  • Recognition Award for Research and Innovation, Healthcare Institute of NJ (2019)
  • Rutgers Board of Trustees Award for Excellence in Research (2011)
  • Election as American Association for the Advancement of Science Fellow (2007)[26]
  • Duncan and Nancy MacMillan Endowed Chair in Genetics (1999-)
  • Elliot Ossermann Award for Distinguished Service in Support of Cancer Research, Israel Cancer Research Fund (1994)
  • Distinguished Alumnus Award and Medal, Brooklyn College of the City University of New York (1990)

References

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  1. ^ The Tischfield’s Lab homepage
  2. ^ "Department of Genetics at Rutgers University".
  3. ^ The Rutgers University Cell & DNA repository Archived 2008-08-08 at the Wayback Machine
  4. ^ United States Patent and Trademark Office
  5. ^ Tan, Y. H.; Tischfield, J.; Ruddle, F. H. (1973). "The Linkage of Genes for the Human Interferon-Induced Antiviral Protein and Indophenol Oxidase-B Traits to Chromosome G-21". The Journal of Experimental Medicine. 137 (2): 317–330. doi:10.1084/jem.137.2.317. PMC 2139494. PMID 4346649.
  6. ^ History of Superoxide dismutase gene discovery in Pubmed
  7. ^ Del Villano, Bert C.; Tischfield, Jay A. (1979). "A radioimmune assay for human cupro-zinc superoxide dismutase and its application to erythrocytes". Journal of Immunological Methods. 29 (3): 253–262. doi:10.1016/0022-1759(79)90313-2. PMID 90710.
  8. ^ Shao, C.; Deng, L.; Henegariu, O.; Liang, L.; Raikwar, N.; Sahota, A.; Stambrook, P. J.; Tischfield, J. A. (1999). "Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice". Proceedings of the National Academy of Sciences of the United States of America. 96 (16): 9230–9235. Bibcode:1999PNAS...96.9230S. doi:10.1073/pnas.96.16.9230. PMC 17762. PMID 10430925.
  9. ^ Tischfield, J. A. (1997). "Loss of heterozygosity or: How I learned to stop worrying and love mitotic recombination". American Journal of Human Genetics. 61 (5): 995–999. doi:10.1086/301617. PMC 1716040. PMID 9345110.
  10. ^ Tischfield, Jay A. (1997). "A Reassessment of the Low Molecular Weight Phospholipase A2 Gene Family in Mammals". Journal of Biological Chemistry. 272 (28): 17247–17250. doi:10.1074/jbc.272.28.17247. PMID 9211858.
  11. ^ Agrawal, A.; Brislin, S. J.; Bucholz, K. K.; Dick, D.; Hart, R. P.; Johnson, E. C.; Meyers, J.; Salvatore, J.; Slesinger, P. (2023). "The Collaborative Study on the Genetics of Alcoholism: Overview". Genes, Brain, and Behavior. 22 (5): e12864. doi:10.1111/gbb.12864. PMC 10550790. PMID 37736010.
  12. ^ Agrawal, A.; Brislin, S. J.; Bucholz, K. K.; Dick, D.; Hart, R. P.; Johnson, E. C.; Meyers, J.; Salvatore, J.; Slesinger, P. (2023). "The Collaborative Study on the Genetics of Alcoholism: Overview". Genes, Brain, and Behavior. 22 (5): e12864. doi:10.1111/gbb.12864. PMC 10550790. PMID 37736010.
  13. ^ Sanders, Stephan J.; et al. (2011). "Multiple Recurrent de Novo CNVS, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism". Neuron. 70 (5): 863–885. doi:10.1016/j.neuron.2011.05.002. PMC 3939065. PMID 21658581.
  14. ^ Dietrich, A.; Fernandez, T. V.; King, R. A.; State, M. W.; Tischfield, J. A.; Hoekstra, P. J.; Heiman, G. A.; the TIC Genetics Collaborative Group (2014). "The Tourette International Collaborative Genetics (TIC Genetics) study, finding the genes causing Tourette syndrome: Objectives and methods". European Child & Adolescent Psychiatry. 24 (2): 141–151. doi:10.1007/s00787-014-0543-x. PMC 4209328. PMID 24771252.
  15. ^ Jay Tischfield’s research
  16. ^ Nasello, Cara; Poppi, Lauren A.; Wu, Junbing; Kowalski, Tess F.; Thackray, Joshua K.; Wang, Riley; Persaud, Angelina; Mahboob, Mariam; Lin, Sherry; Spaseska, Rodna; Johnson, C. K.; Gordon, Derek; Tissir, Fadel; Heiman, Gary A.; Tischfield, Jay A.; Bocarsly, Miriam; Tischfield, Max A. (2024). "Human mutations in high-confidence Tourette disorder genes affect sensorimotor behavior, reward learning, and striatal dopamine in mice". Proceedings of the National Academy of Sciences. 121 (19): e2307156121. Bibcode:2024PNAS..12107156N. doi:10.1073/pnas.2307156121. PMC 11087812. PMID 38683996.
  17. ^ "Tischfield%20and%20Tourette.HTML - Search Results".
  18. ^ Wang, S.; et al. (2023). "Rare X-linked variants carry predominantly male risk in autism, Tourette syndrome, and ADHD". Nature Communications. 14 (1): 8077. Bibcode:2023NatCo..14.8077W. doi:10.1038/s41467-023-43776-0. PMC 10700338. PMID 38057346.
  19. ^ Nasello, Cara; Poppi, Lauren A.; Wu, Junbing; Kowalski, Tess F.; Thackray, Joshua K.; Wang, Riley; Persaud, Angelina; Mahboob, Mariam; Lin, Sherry; Spaseska, Rodna; Johnson, C. K.; Gordon, Derek; Tissir, Fadel; Heiman, Gary A.; Tischfield, Jay A.; Bocarsly, Miriam; Tischfield, Max A. (2024). "Human mutations in high-confidence Tourette disorder genes affect sensorimotor behavior, reward learning, and striatal dopamine in mice". Proceedings of the National Academy of Sciences. 121 (19): e2307156121. Bibcode:2024PNAS..12107156N. doi:10.1073/pnas.2307156121. PMC 11087812. PMID 38683996.
  20. ^ "Tischfield J%24.HTML - Search Results - PubMed".
  21. ^ NJBIZ The 100 most powerful people in New Jersey business
  22. ^ "Tischfield, Max".
  23. ^ [1]
  24. ^ David Tischfield linkdin
  25. ^ a b A most unusual Collector
  26. ^ List of AAAS Fellows Archived 2014-01-15 at the Wayback Machine
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