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KDM3A

From Wikipedia, the free encyclopedia
KDM3A
Identifiers
AliasesKDM3A, JHDM2A, JHMD2A, JMJD1, JMJD1A, TSGA, lysine demethylase 3A
External IDsOMIM: 611512; MGI: 98847; HomoloGene: 10196; GeneCards: KDM3A; OMA:KDM3A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001146688
NM_018433

NM_001038695
NM_173001
NM_001362200
NM_001362201

RefSeq (protein)

NP_001140160
NP_060903

NP_001033784
NP_766589
NP_001349129
NP_001349130

Location (UCSC)Chr 2: 86.44 – 86.49 MbChr 6: 71.57 – 71.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lysine demethylase 3A is a protein that in humans is encoded by the KDM3A gene.[5]

Function

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This gene encodes a zinc finger protein that contains a jumonji C (JmjC) domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants. KDM3A catalyzes the demethylation of H3K9me1 and H3K9me2 residues. Its function is dependent on the presence of cofactors Fe(II) and α-Ketoglutarate.[6]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115548Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053470Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Lysine demethylase 3A".
  6. ^ Yamane K, Toumazou C, Tsukada Y, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y (May 2006). "JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor". Cell. 125 (3): 483–495. doi:10.1016/j.cell.2006.03.027. PMID 16603237. S2CID 6643329.

Further reading

[edit]
  • Wellmann S, Bettkober M, Zelmer A, Seeger K, Faigle M, Eltzschig HK, Bührer C (August 2008). "Hypoxia upregulates the histone demethylase JMJD1A via HIF-1". Biochemical and Biophysical Research Communications. 372 (4): 892–897. doi:10.1016/j.bbrc.2008.05.150. PMID 18538129.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.