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KLC1

From Wikipedia, the free encyclopedia
KLC1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKLC1, KLC, KNS2, KNS2A, kinesin light chain 1
External IDsOMIM: 600025; MGI: 107978; HomoloGene: 4056; GeneCards: KLC1; OMA:KLC1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_182923
NM_001130107
NM_005552

RefSeq (protein)

NP_001123579
NP_005543
NP_891553

n/a

Location (UCSC)Chr 14: 103.56 – 103.71 MbChr 12: 111.73 – 111.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kinesin light chain 1 is a protein that in humans is encoded by the KLC1 gene.[5][6][7]

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature of some of these variants has not been determined.[7]

Interactions

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KLC1 has been shown to interact with MAPK8IP3,[6] KIF5B[8][9][10] and KIF5A.[9][10]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000126214Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021288Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cabeza-Arvelaiz Y, Shih LC, Hardman N, Asselbergs F, Bilbe G, Schmitz A, White B, Siciliano MJ, Lachman LB (Feb 1994). "Cloning and genetic characterization of the human kinesin light-chain (KLC) gene". DNA Cell Biol. 12 (10): 881–92. doi:10.1089/dna.1993.12.881. PMID 8274221.
  6. ^ a b Bowman AB, Kamal A, Ritchings BW, Philp AV, McGrail M, Gindhart JG, Goldstein LS (Jan 2001). "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. 103 (4): 583–94. doi:10.1016/S0092-8674(00)00162-8. PMID 11106729.
  7. ^ a b "Entrez Gene: KNS2 kinesin 2".
  8. ^ Diefenbach, Russell J; Diefenbach Eve; Douglas Mark W; Cunningham Anthony L (Dec 2002). "The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23". Biochemistry. 41 (50): 14906–15. doi:10.1021/bi026417u. ISSN 0006-2960. PMID 12475239.
  9. ^ a b Rahman, A; Friedman D S; Goldstein L S (Jun 1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins". J. Biol. Chem. 273 (25): 15395–403. doi:10.1074/jbc.273.25.15395. ISSN 0021-9258. PMID 9624122.
  10. ^ a b Rahman, A; Kamal A; Roberts E A; Goldstein L S (Sep 1999). "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants". J. Cell Biol. 146 (6): 1277–88. doi:10.1083/jcb.146.6.1277. ISSN 0021-9525. PMC 2156125. PMID 10491391.

Further reading

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