L-701324
quinolin-2(1H)-one.png)
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| Names | |
|---|---|
| IUPAC name
7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-1H-quinolin-2-one
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| Identifiers | |
PubChem CID
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| Properties | |
| C21H14ClNO3 | |
| Molar mass | 363.80 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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L-701324 is an antagonist of the N-methyl-D-aspartic acid receptor, it appears to have antidepressant activity.
Pharmacology
[edit]L-701324 appears to be an antagonist of the N-methyl-D-aspartic acid receptor, and acts at the glycine binding site.[1] This means that it prevents the receptor from activating by blocking the binding of glycine, a required co-agonist in addition to glutamate.
Potential use as an antidepressant
[edit]L-701324 exhibited antidepressant behavior in mice, by reducing depression-like behavior caused by the forced swimming test, the Tail suspension test, and the chronic unpredictable mild stress model.[2]
Another study was also performed, it combined an adenosine antagonist (in this case, caffeine), L-701324 and other ligands, the study shows that combining NMDA antagonists and adenosine antagonists might be a future option for antidepressants.[3]
References
[edit]- ^ Priestley, T.; Laughton, P.; Macaulay, A. J.; Hill, R. G.; Kemp, J. A. (1996). "Electrophysiological characterisation of the antagonist properties of two novel NMDA receptor glycine site antagonists, L-695,902 and L-701,324". Neuropharmacology. 35 (11): 1573–1581. doi:10.1016/s0028-3908(96)00141-4. ISSN 0028-3908. PMID 9025105.
- ^ Liu, Ling; Ji, Chun-Hui; Wang, Yuan; Zhao, Jie; Liu, Yue; Tang, Wen-Qian; Gu, Jiang-Hong; Jiang, Bo (2021-02-05). "Antidepressant-like activity of L-701324 in mice: A behavioral and neurobiological characterization". Behavioural Brain Research. 399: 113038. doi:10.1016/j.bbr.2020.113038. ISSN 1872-7549. PMID 33276033.
- ^ Serefko, Anna; Szopa, Aleksandra; Wlaź, Aleksandra; Wośko, Sylwia; Wlaź, Piotr; Poleszak, Ewa (2016-04-01). "Synergistic antidepressant-like effect of the joint administration of caffeine and NMDA receptor ligands in the forced swim test in mice". Journal of Neural Transmission. 123 (4): 463–472. doi:10.1007/s00702-015-1467-4. ISSN 1435-1463. PMC 4805709. PMID 26510772.