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Lactate dehydrogenase b

From Wikipedia, the free encyclopedia
LDHB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLDHB, HEL-S-281, LDH-B, LDH-H, LDHBD, TRG-5, lactate dehydrogenase B
External IDsOMIM: 150100; MGI: 96763; HomoloGene: 55647; GeneCards: LDHB; OMA:LDHB - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001174097
NM_002300
NM_001315537

NM_008492
NM_001302765
NM_001316322

RefSeq (protein)

NP_001167568
NP_001302466
NP_002291

NP_001289694
NP_001303251
NP_032518

Location (UCSC)Chr 12: 21.64 – 21.76 MbChr 6: 142.44 – 142.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lactate dehydrogenase B is a protein that in humans is encoded by the LDHB gene. [5]

Function

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This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111716Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030246Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Lactate dehydrogenase B". Retrieved 2017-10-01.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.