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MAL2 (gene)

From Wikipedia, the free encyclopedia
MAL2
Identifiers
AliasesMAL2, mal, T-cell differentiation protein 2 (gene/pseudogene), mal, T cell differentiation protein 2 (gene/pseudogene), mal, T cell differentiation protein 2
External IDsOMIM: 609684; MGI: 2146021; HomoloGene: 14167; GeneCards: MAL2; OMA:MAL2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_052886

NM_178920

RefSeq (protein)

NP_443118
NP_443118.1

NP_849251

Location (UCSC)Chr 8: 119.17 – 119.25 MbChr 15: 54.43 – 54.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein MAL2 is a protein that in humans is encoded by the MAL2 gene.[5][6]

This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface.[6]

Interactions

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MAL2 (gene) has been shown to interact with TPD52.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147676Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024479Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Wilson SH, Bailey AM, Nourse CR, Mattei MG, Byrne JA (Sep 2001). "Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system". Genomics. 76 (1–3): 81–8. doi:10.1006/geno.2001.6610. PMID 11549320.
  6. ^ a b "Entrez Gene: MAL2 mal, T-cell differentiation protein 2".

Further reading

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