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MED19

From Wikipedia, the free encyclopedia
MED19
Identifiers
AliasesMED19, DT2P1G7, LCMR1, MED19AS, mediator complex subunit 19
External IDsOMIM: 612385; MGI: 1914234; HomoloGene: 14684; GeneCards: MED19; OMA:MED19 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_153450
NM_001317078

NM_025885

RefSeq (protein)

NP_001304007
NP_703151

NP_080161

Location (UCSC)Chr 11: 57.7 – 57.71 MbChr 2: 84.51 – 84.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mediator complex subunit 19 (Med19) is a protein that in humans is encoded by the MED19 gene. [5]

Function

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The protein encoded by this gene is a subunit of the Mediator complex, which binds to gene-specific regulatory factors and provides support for the basal RNA polymerase II transcription machinery. This gene has been implicated in the growth of several types of cancer, and inhibition of its expression inhibits the growth and spread of these cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015].

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000156603Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027080Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Mediator complex subunit 19". Retrieved 2018-02-06.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.