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MKL2

From Wikipedia, the free encyclopedia

MRTFB
Identifiers
AliasesMRTFB, MRTF-B, NPD001, MKL1/myocardin like 2, myocardin related transcription factor B, MKL2
External IDsOMIM: 609463; MGI: 3050795; HomoloGene: 40917; GeneCards: MRTFB; OMA:MRTFB - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001308142
NM_014048

NM_001122667
NM_153588
NM_181860

RefSeq (protein)

NP_001116139
NP_705816
NP_862908

Location (UCSC)Chr 16: 14.07 – 14.27 MbChr 16: 13.07 – 13.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MKL/myocardin-like protein 2 is a protein that in humans is encoded by the MKL2 gene.[5][6]

Members of the myocardin family bind to the transcription factor serum response factor (SRF) and act as coactivators controlling genes of relevance for myogenic differentiation, motile function [7] and addiction. [8]



References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186260Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009569Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Jan 2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
  6. ^ "Entrez Gene: MKL2 MKL/myocardin-like 2".
  7. ^ Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (September 2016). "Emerging roles of the myocardin family of proteins in lipid and glucose metabolism". J Physiol. 594 (17): 4741–4752. doi:10.1113/JP271913. PMC 5009794. PMID 27060572.
  8. ^ Ariza A, Funahashi Y, Kozawa S, Faruk MO, Nagai T, Amano M, Kaibuchi K (2021). "Dynamic subcellular localization and transcription activity of the SRF cofactor MKL2 in the striatum are regulated by MAPK". Journal of Neurochemistry. 157 (6): 1774–1788. doi:10.1111/jnc.15303. PMID 33449379. S2CID 231613803.

Further reading

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