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MRPS25

From Wikipedia, the free encyclopedia
MRPS25
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPS25, MRP-S25, RPMS25, mitochondrial ribosomal protein S25, COXPD50
External IDsOMIM: 611987; MGI: 1928140; HomoloGene: 11207; GeneCards: MRPS25; OMA:MRPS25 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022497

NM_025578

RefSeq (protein)

NP_071942

NP_079854

Location (UCSC)Chr 3: 15.01 – 15.07 MbChr 6: 92.15 – 92.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

28S ribosomal protein S25, mitochondrial is a protein that in humans is encoded by the MRPS25 gene.[5][6]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 4.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131368Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014551Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.
  6. ^ a b "Entrez Gene: MRPS25 mitochondrial ribosomal protein S25".

Further reading

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[edit]
  • Overview of all the structural information available in the PDB for UniProt: P82663 (28S ribosomal protein S25, mitochondrial) at the PDBe-KB.