Macro-creatine kinase
Macro-creatine kinase (macro-CK) is a macroenzyme, an enzyme of high molecular weight and prolonged half-life found in human serum.[1] It is one of the most common macroenzymes.[1] Macro-CK type 1 is a complex formed by one of the creatine kinase isoenzyme types, typically CK-BB, and antibodies; typically IgG, sometimes IgA, rarely IgM. Macro-CK type 2 is formed from mitochondrial CK polymer.[2]
Macro-CK type 1 has been associated with autoimmune and other chronic conditions.[1] Macro-CK type 2 has been associated with malignancy.[1]
Macro-CK has been implicated as a source of interference in interpretation of medical labs.[3]
References
[edit]- ^ a b c d Horino, T; Ichii, O; Ode-Hamada, K; Terada, Y (1 September 2017). "Macromolecular creatine kinase type 1 in immune-mediated necrotizing myopathy". QJM: Monthly Journal of the Association of Physicians. 110 (9): 593–594. doi:10.1093/qjmed/hcx113. PMID 28633310.
- ^ Zhang, L; Han, F; Liu, X; Xie, C; Tian, K; Bi, Q; Hao, M; Mu, X (6 August 2020). "Macro creatine kinase in an asymptomatic patient: a case report". Clinical Chemistry and Laboratory Medicine. 59 (2): e61–e64. doi:10.1515/cclm-2020-0811. PMID 32759404. S2CID 221036708.
- ^ Straseski, Joely A.; Wyness, Sara P. (September 2016). "When Big Complexes Cause Big Problems | AACC.org". www.aacc.org. Archived from the original on 25 November 2021. Retrieved 31 March 2022.