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Maleimide hydrolase

From Wikipedia, the free encyclopedia
maleimide hydrolase
Identifiers
EC no.3.5.2.16
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a maleimide hydrolase (EC 3.5.2.16) is an enzyme that catalyzes the chemical reaction

maleimide + H2O maleamic acid

Thus, the two substrates of this enzyme are maleimide and H2O, whereas its product is maleamic acid.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is cyclic-imide amidohydrolase (decyclizing). Other names in common use include imidase, cyclic imide hydrolase, and cyclic-imide amidohydrolase (decyclicizing) [misprint].

References

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  • Ogawa J, Soong CL, Honda M, Shimizu S (1997). "Imidase, a dihydropyrimidinase-like enzyme involved in the metabolism of cyclic imides". Eur. J. Biochem. 243 (1–2): 322–7. doi:10.1111/j.1432-1033.1997.0322a.x. PMID 9030755.