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Mesoderm-specific transcript homolog protein

From Wikipedia, the free encyclopedia
MEST
Identifiers
AliasesMEST, PEG1, mesoderm specific transcript
External IDsOMIM: 601029; MGI: 96968; HomoloGene: 1800; GeneCards: MEST; OMA:MEST - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001252292
NM_001252293
NM_008590

RefSeq (protein)

NP_001239221
NP_001239222
NP_032616

Location (UCSC)Chr 7: 130.49 – 130.51 MbChr 6: 30.72 – 30.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mesoderm-specific transcript homolog protein is a protein that in humans is encoded by the MEST gene.[5][6]

This gene encodes a member of the Alpha/beta hydrolase superfamily and has isoform-specific imprinting. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promoter switching. The encoded protein may play a role in development. Three transcript variants encoding two distinct isoforms have been identified for this gene. A pseudogene for this locus is located on chromosome 6.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106484Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051855Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nishita Y, Yoshida I, Sado T, Takagi N (Feb 1997). "Genomic imprinting and chromosomal localization of the human MEST gene". Genomics. 36 (3): 539–42. doi:10.1006/geno.1996.0502. PMID 8884280.
  6. ^ a b "Entrez Gene: MEST mesoderm specific transcript homolog (mouse)".

Further reading

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