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Methanol—5-hydroxybenzimidazolylcobamide Co-methyltransferase

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methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase
Identifiers
EC no.2.1.1.90
CAS no.86611-98-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase (EC 2.1.1.90) is an enzyme that catalyzes the chemical reaction

methanol + 5-hydroxybenzimidazolylcobamide Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide + H2O

Thus, the two substrates of this enzyme are methanol and 5-hydroxybenzimidazolylcobamide, whereas its two products are Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide and H2O.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase. Other names in common use include methanol cobalamin methyltransferase, methanol:5-hydroxybenzimidazolylcobamide methyltransferase, and MT 1.

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2I2X.

References

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Further reading

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  • van der Meijden P, te Brömmelstroet BW, Poirot CM, van der Drift C, Vogels GD (November 1984). "Purification and properties of methanol:5-hydroxybenzimidazolylcobamide methyltransferase from Methanosarcina barkeri". Journal of Bacteriology. 160 (2): 629–35. doi:10.1128/JB.160.2.629-635.1984. PMC 214781. PMID 6438059.