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Mitogen-activated protein kinase kinase kinase 6

From Wikipedia, the free encyclopedia
MAP3K6
Identifiers
AliasesMAP3K6, ASK2, MAPKKK6, MEKK6, mitogen-activated protein kinase kinase kinase 6
External IDsOMIM: 604468; MGI: 1855691; HomoloGene: 3435; GeneCards: MAP3K6; OMA:MAP3K6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001297609
NM_004672
NM_145319

NM_016693

RefSeq (protein)

NP_001284538
NP_004663

NP_057902

Location (UCSC)Chr 1: 27.35 – 27.37 MbChr 4: 132.97 – 132.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitogen-activated protein kinase kinase kinase 6 is a protein that in humans is encoded by the MAP3K6 gene. [5]

Function

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This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000142733Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028862Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Mitogen-activated protein kinase kinase kinase 6". Retrieved 2018-07-10.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.