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Myod family inhibitor domain containing

From Wikipedia, the free encyclopedia
MDFIC
Identifiers
AliasesMDFIC, HIC, MyoD family inhibitor domain containing, MDFIC1
External IDsOMIM: 614511; MGI: 104611; HomoloGene: 18404; GeneCards: MDFIC; OMA:MDFIC - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_199072
NM_001166345
NM_001166346

NM_175088

RefSeq (protein)

NP_001159817
NP_001159818
NP_951038

NP_780297

Location (UCSC)Chr 7: 114.92 – 115.02 MbChr 6: 15.72 – 15.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MyoD family inhibitor domain containing is a protein that in humans is encoded by the MDFIC gene. [5]

Function

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This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135272Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041390Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: MyoD family inhibitor domain containing". Retrieved 2016-02-09.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.