Jump to content

NK012

From Wikipedia, the free encyclopedia

NK012 is a 'nanodevice' formulation of SN-38 (an irinotecan metabolite). NK012 is an SN-38-releasing polymeric micelle constructed by covalently attaching SN-38 to the block copolymer PEG-PGlu, followed by self-assembly of amphiphilic block copolymers in aqueous media.[1] [2]

It has completed phase II clinical trials for triple-negative breast cancer and relapsed small cell lung cancer.[3] In 2016, Nippon Kayaku received orphan drug designation for NK012 from the US FDA.[4] This means that if it is approved in the United States, Nippon Kayaku will be entitled to 7 years of market exclusivity. This is intended to incentivize future development, but does not mean the drug has been approved.[citation needed]

See also

[edit]

References

[edit]
  1. ^ "NCI Drug Dictionary". National Cancer Institute. 2011-02-02. Retrieved 2020-11-28.
  2. ^ Sumitomo; et al. (2008). "Novel SN-38–Incorporated Polymeric Micelle, NK012, Strongly Suppresses Renal Cancer Progression". Cancer Research. 68 (6): 1631–1635. doi:10.1158/0008-5472.CAN-07-6532. PMID 18339841.
  3. ^ "Search of: NK012 - List Results - ClinicalTrials.gov". www.clinicaltrials.gov. Retrieved 2020-11-28.
  4. ^ Nippon Kayaku Announces FDA Orphan Drug Designation to New Polymeric micelle Anti-Cancer Drug NK012 for Small Cell Lung Cancer. (2016). Evaluategroup.com. Retrieved 24 November 2017, from http://www.evaluategroup.com/Universal/View.aspx?type=Story&id=644017