NME3

NME3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZS6
Identifiers
Aliases	NME3, DR-nm23, NDPK-C, NDPKC, NM23-H3, NM23H3, c371H6.2, NME/NM23 nucleoside diphosphate kinase 3
External IDs	OMIM: 601817 MGI: 1930182 HomoloGene: 20562 GeneCards: NME3
Gene location (Human)
Chr.	Chromosome 16 (human)
End	1,771,561 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	25,116,496 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; right adrenal gland; ; right uterine tube; ; canal of the cervix; ; gastric mucosa; ; left uterine tube; ; ascending aorta; ; right coronary artery; ; left coronary artery; ; right lobe of thyroid gland;
	Top expressed in
	bone marrow; ; pancreas; ; adrenal gland; ; islet of Langerhans; ; urinary bladder; ; proximal tubule; ; hypothalamus; ; yolk sac; ; neural tube; ; kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	kinase activity; nucleotide binding; transferase activity; protein binding; ATP binding; metal ion binding; nucleoside diphosphate kinase activity;
Cellular component	cytosol; intracellular anatomical structure;
Biological process	UTP biosynthetic process; apoptotic process; CTP biosynthetic process; GTP biosynthetic process; nucleotide metabolic process; nucleoside diphosphate phosphorylation; phosphorylation; nucleobase-containing small molecule interconversion; regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	4832
	79059
	ENSG00000103024
	ENSMUSG00000073435
	Q13232
	Q9WV85
	NM_002513
	NM_019730
	NP_002504
	NP_062704
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleoside diphosphate kinase 3 is an enzyme that in humans is encoded by the NME3 gene.^[5]^[6]

Interactions[edit]

NME3 has been shown to interact with NME1^[7]^[8] and NME2.^[8]^[9]

Clinical significance[edit]

Mutations in this gene have been associated with congenital hypotonia, hypoventilation and cerebellar histopathological alterations.^[10]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103024 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000073435 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Martinez R, Venturelli D, Perrotti D, Veronese ML, Kastury K, Druck T, Huebner K, Calabretta B (March 1997). "Gene structure, promoter activity, and chromosomal location of the DR-nm23 gene, a related member of the nm23 gene family". Cancer Research. 57 (6): 1180–7. PMID 9067290.
^ "Entrez Gene: NME3 non-metastatic cells 3, protein expressed in".
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
^ ^a ^b Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G (September 2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death and Differentiation. 7 (9): 843–50. doi:10.1038/sj.cdd.4400720. hdl:11380/695506. PMID 11042679.
^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
^ Chen CW, Wang HL, Huang CW, Huang CY, Lim WK, Tu IC, Koorapati A, Hsieh ST, Kan HW, Tzeng SR, Liao JC, Chong WM, Naroditzky I, Kidron D, Eran A, Nijim Y, Sela E, Feldman HB, Kalfon L, Raveh-Barak H, Falik-Zaccai TC, Elpeleg O, Mandel H, Chang ZF (December 2018). "Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder". Proceedings of the National Academy of Sciences of the United States of America. 116 (2): 566–574. doi:10.1073/pnas.1818629116. PMC 6329951. PMID 30587587.

External links[edit]

Overview of all the structural information available in the PDB for UniProt: Q13232 (Nucleoside diphosphate kinase 3) at the PDBe-KB.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000103024 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000073435 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9067290-5] Martinez R, Venturelli D, Perrotti D, Veronese ML, Kastury K, Druck T, Huebner K, Calabretta B (March 1997). "Gene structure, promoter activity, and chromosomal location of the DR-nm23 gene, a related member of the nm23 gene family". Cancer Research. 57 (6): 1180–7. PMID 9067290.

[entrez-6] "Entrez Gene: NME3 non-metastatic cells 3, protein expressed in".

[pmid16189514-7] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[pmid11042679-8] Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G (September 2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death and Differentiation. 7 (9): 843–50. doi:10.1038/sj.cdd.4400720. hdl:11380/695506. PMID 11042679.

[pmid16169070-9] Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.

[Chen_2018-10] Chen CW, Wang HL, Huang CW, Huang CY, Lim WK, Tu IC, Koorapati A, Hsieh ST, Kan HW, Tzeng SR, Liao JC, Chong WM, Naroditzky I, Kidron D, Eran A, Nijim Y, Sela E, Feldman HB, Kalfon L, Raveh-Barak H, Falik-Zaccai TC, Elpeleg O, Mandel H, Chang ZF (December 2018). "Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder". Proceedings of the National Academy of Sciences of the United States of America. 116 (2): 566–574. doi:10.1073/pnas.1818629116. PMC 6329951. PMID 30587587.

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Interactions[edit]

Clinical significance[edit]

References[edit]

Further reading[edit]

External links[edit]