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NUDCD3

From Wikipedia, the free encyclopedia
NUDCD3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNUDCD3, NudCL, NudC domain containing 3
External IDsOMIM: 610296; MGI: 2144158; HomoloGene: 9097; GeneCards: NUDCD3; OMA:NUDCD3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015332

NM_173748
NM_001363446

RefSeq (protein)

NP_056147

NP_776109
NP_001350375

Location (UCSC)Chr 7: 44.38 – 44.49 MbChr 11: 6.06 – 6.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NudC domain-containing protein 3 is a protein that in humans is encoded by the NUDCD3 gene.[5]

Function

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The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000015676Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053838Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: NUDCD3 NudC domain containing 3".

Further reading

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