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NUTF2

From Wikipedia, the free encyclopedia
NUTF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNUTF2, NTF2, PP15, NTF-2, nuclear transport factor 2
External IDsOMIM: 605813; MGI: 3704482; HomoloGene: 110745; GeneCards: NUTF2; OMA:NUTF2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005796
NM_001322038
NM_001322039
NM_001322040
NM_001322041

XM_001473957

RefSeq (protein)

NP_080808
NP_001344158
NP_001344159

Location (UCSC)Chr 16: 67.85 – 67.87 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Nuclear transport factor 2 is a protein that in humans is encoded by the NUTF2 gene.[4][5][6]

Function

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The protein encoded by this gene is a cytosolic factor that facilitates protein transport into the nucleus. It interacts with the nuclear pore complex glycoprotein p62. This encoded protein acts at a relative late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. It is thought to be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.[6]

Interactions

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NUTF2 has been shown to interact with Nucleoporin 62[4][7] and RAN.[8][9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102898Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ a b Paschal BM, Gerace L (Jun 1995). "Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62". J Cell Biol. 129 (4): 925–937. doi:10.1083/jcb.129.4.925. PMC 2120498. PMID 7744965.
  5. ^ Grundmann U, Nerlich C, Rein T, Lottspeich F, Küpper HA (Jul 1988). "Isolation of cDNA coding for the placental protein 15 (PP15)". Nucleic Acids Res. 16 (10): 4721. doi:10.1093/nar/16.10.4721. PMC 336660. PMID 3380696.
  6. ^ a b "Entrez Gene: NUTF2 nuclear transport factor 2".
  7. ^ Hu T, Guan T, Gerace L (Aug 1996). "Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins". J. Cell Biol. 134 (3): 589–601. doi:10.1083/jcb.134.3.589. PMC 2120945. PMID 8707840.
  8. ^ Cushman I, Bowman BR, Sowa ME, Lichtarge O, Quiocho FA, Moore MS (Nov 2004). "Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2". J. Mol. Biol. 344 (2): 303–310. doi:10.1016/j.jmb.2004.09.043. PMID 15522285.
  9. ^ Stewart M, Kent HM, McCoy AJ (Apr 1998). "Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran". J. Mol. Biol. 277 (3): 635–646. doi:10.1006/jmbi.1997.1602. PMID 9533885.

Further reading

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