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Neil Brockdorff

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Neil Brockdorff
FRS FMedSci FRSB
Neil Brockdorff at the Royal Society in London, July 2018
Born
Neil Alexander Steven Brockdorff

1958 (age 65–66)[3]
EducationHampstead School[3]
Alma materUniversity of Sussex (BSc)
University of Glasgow (PhD)[4]
AwardsEMBO Member (1999)[1]
Scientific career
FieldsDevelopmental epigenetics
X inactivation[2]
InstitutionsUniversity of Oxford
ThesisThe effect of oestradiol-17β on the ribonucleases and ribonuclease inhibitor of immature rat uterus (1985)
Websitewww.bioch.ox.ac.uk/research/brockdorff

Neil Alexander Steven Brockdorff (born 1958) is a British biochemist who is a Wellcome Trust Principal Research Fellow and professor in the department of biochemistry at the University of Oxford.[5][6] Brockdorff's research investigates gene and genome regulation in mammalian development.[7] His interests are in the molecular basis of X-inactivation, the process that evolved in mammals to equalise X chromosome gene expression levels in XX females relative to XY males.[7]

Education

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Brockdorff was educated at Hampstead School, the University of Sussex (BSc)[3] and the University of Glasgow (PhD).[4]

Career and research

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X inactivation is an important model for understanding how epigenetic mechanisms, for example modification of DNA and histone proteins around which DNA is packaged, contribute to gene regulation in developmental biology.[7][8] In earlier work Brockdorff demonstrated that an unusual functional RNA molecule, XIST, controls the X inactivation process.[9][10] Building on this finding he has elucidated key steps in XIST gene regulation during early development, and has defined major pathways through which XIST RNA induces chromosome wide gene silencing.[7][11][12][13]

Awards and honours

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Brockdorff is a member of the European Molecular Biology Organization (EMBO), a Fellow of the Royal Society (FRS), a Fellow of the Academy of Medical Sciences (FMedSci) and a Fellow of the Royal Society of Biology (FRSB).

References

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  1. ^ "EMBO MEMBER: Neil Brockdorff". people.embo.org. Retrieved 12 June 2018.
  2. ^ Brockdorff, Neil (2017). "Polycomb complexes in X chromosome inactivation". Philosophical Transactions of the Royal Society B. 372 (1733). doi:10.1098/rstb.2017.0021. ISSN 0962-8436. PMC 5627167. PMID 28947664.
  3. ^ a b c Anon (2019). "Brockdorff, Prof. Neil". Who's Who (online Oxford University Press ed.). Oxford: A & C Black. (Subscription or UK public library membership required.)
  4. ^ a b Brockdorff, Neil Alexander Steven (1985). The effect of oestradiol-17β on the ribonucleases and ribonuclease inhibitor of immature rat uterus. jisc.ac.uk (PhD thesis). University of Glasgow. OCLC 301485805. EThOS uk.bl.ethos.379306.
  5. ^ "Brockdorff Lab". sites.google.com. Retrieved 12 June 2018.
  6. ^ "Prof Neil Brockdorff Page - Department of Biochemistry, University of Oxford". www.bioch.ox.ac.uk. Retrieved 12 June 2018.
  7. ^ a b c d Anon (2018). "Professor Neil Brockdorff FRS". royalsociety.org. London: Royal Society. Archived from the original on 6 June 2018. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)
  8. ^ de Napoles, Mariana; Mermoud, Jacqueline E.; Wakao, Rika; Tang, Y.Amy; Endoh, Mitusuhiro; Appanah, Ruth; Nesterova, Tatyana B.; Silva, Jose; Otte, Arie P.; Vidal, Miguel; Koseki, Haruhiko; Brockdorff, Neil (2004). "Polycomb Group Proteins Ring1A/B Link Ubiquitylation of Histone H2A to Heritable Gene Silencing and X Inactivation". Developmental Cell. 7 (5): 663–676. doi:10.1016/j.devcel.2004.10.005. ISSN 1534-5807. PMID 15525528. Free access icon
  9. ^ Penny, Graeme D.; Kay, Graham F.; Sheardown, Steven A.; Rastan, Sohaila; Brockdorff, Neil (1996). "Requirement for Xist in X chromosome inactivation". Nature. 379 (6561): 131–137. Bibcode:1996Natur.379..131P. doi:10.1038/379131a0. ISSN 0028-0836. PMID 8538762. S2CID 4329368.
  10. ^ Brockdorff, Neil; Ashworth, Alan; Kay, Graham F.; McCabe, Veronica M.; Norris, Dominic P.; Cooper, Penny J.; Swift, Sally; Rastan, Sohaila (1992). "The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus". Cell. 71 (3): 515–526. doi:10.1016/0092-8674(92)90519-I. ISSN 0092-8674. PMID 1423610. S2CID 19889657.
  11. ^ Heard, Edith; Brockdorff, Neil (2017). "Preface: X-chromosome inactivation and Mary Lyon". Philosophical Transactions of the Royal Society B. 372 (1733). doi:10.1098/rstb.2016.0353. ISSN 0962-8436. PMC 5627156. PMID 28947653. Open access icon
  12. ^ Neil Brockdorff publications from Europe PubMed Central
  13. ^ Stock, Julie K.; Giadrossi, Sara; Casanova, Miguel; Brookes, Emily; Vidal, Miguel; Koseki, Haruhiko; Brockdorff, Neil; Fisher, Amanda G.; Pombo, Ana (2007). "Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells". Nature Cell Biology. 9 (12): 1428–1435. doi:10.1038/ncb1663. hdl:10261/61600. ISSN 1465-7392. PMID 18037880. S2CID 2317691. Closed access icon

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