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Nickel-transporting ATPase

From Wikipedia, the free encyclopedia
nickel-transporting ATPase
Identifiers
EC no.3.6.3.24
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins

In enzymology, a nickel-transporting ATPase (EC 3.6.3.24) is an enzyme that catalyzes the chemical reaction

ATP + H2O + Ni2+out ADP + phosphate + Ni2+in

The 3 substrates of this enzyme are ATP, H2O, and Ni2+, whereas its 3 products are ADP, phosphate, and Ni2+.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (nickel-importing).

Structural studies

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As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1ZLQ and 2NOO.

References

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  • Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH (1995). "Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases". Res. Microbiol. 146 (4): 271–8. doi:10.1016/0923-2508(96)81050-3. PMID 7569321.
  • Hendricks JK, Mobley HL (1997). "Helicobacter pylori ABC transporter: effect of allelic exchange mutagenesis on urease activity". J. Bacteriol. 179 (18): 5892–902. doi:10.1128/jb.179.18.5892-5902.1997. PMC 179482. PMID 9294450.
  • Saier MH (1998). "Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya". Adv. Microb. Physiol. Advances in Microbial Physiology. 40: 81–136. doi:10.1016/S0065-2911(08)60130-7. ISBN 9780120277407. PMID 9889977.
  • Griffiths JK; Sansom CE. "The Transporter Factsbook, Academic Press, San Diego, 1998". {{cite journal}}: Cite journal requires |journal= (help)