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O-phospho-L-serine—tRNA ligase

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O-Phospho-L-serine—tRNA ligase
Identifiers
EC no.6.1.1.27
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
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MetaCycmetabolic pathway
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O-phospho-L-serine—tRNA ligase (EC 6.1.1.27, O-phosphoseryl-tRNA ligase, non-canonical O-phosphoseryl-tRNA synthetase, SepRS) is an enzyme with systematic name O-phospho-L-serine:tRNACys ligase (AMP-forming).[1][2] This enzyme catalyses the following chemical reaction:

ATP + O-phospho-L-serine + tRNACys AMP + diphosphate + O-phospho-L-seryl-tRNACys

In organisms like Archaeoglobus fulgidus, this enzyme ligates O-phosphoserine to tRNACys.

References

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  1. ^ Fukunaga R, Yokoyama S (April 2007). "Structural insights into the first step of RNA-dependent cysteine biosynthesis in archaea". Nature Structural & Molecular Biology. 14 (4): 272–9. doi:10.1038/nsmb1219. PMID 17351629. S2CID 10959763.
  2. ^ Hauenstein SI, Perona JJ (August 2008). "Redundant synthesis of cysteinyl-tRNACys in Methanosarcina mazei". The Journal of Biological Chemistry. 283 (32): 22007–17. doi:10.1074/jbc.M801839200. PMC 2494925. PMID 18559341.
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