Olfactomedin 4

OLFM4
Identifiers
Aliases	OLFM4, GC1, GW112, OLM4, OlfD, UNQ362, bA209J19.1, hGC-1, hOLfD, olfactomedin 4
External IDs	OMIM: 614061 MGI: 2685142 HomoloGene: 4684 GeneCards: OLFM4
Gene location (Human) Chr. Chromosome 13 (human) Band 13q14.3 Start 53,028,813 bp End 53,052,057 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 D3 Start 80,221,521 bp End 80,260,579 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in urethra jejunal mucosa duodenum rectum cecum appendix bone marrow trabecular bone bone marrow cells body of pancreas Top expressed in Paneth cell duodenum ileum jejunum conjunctival fornix islet of Langerhans otolith organ utricle sexually immature organism kidney More reference expression data BioGPS n/a
Gene ontology Molecular function catalytic activity protein binding protein homodimerization activity cadherin binding Cellular component perinuclear region of cytoplasm plasma membrane azurophil granule specific granule extracellular exosome secretory granule mitochondrion extracellular region extracellular space specific granule lumen tertiary granule lumen Biological process regulation of apoptotic process positive regulation of substrate adhesion-dependent cell spreading regulation of phagocytosis cell adhesion protein homooligomerization regulation of necrotic cell death regulation of neutrophil extravasation neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10562 380924 Ensembl ENSG00000102837 ENSMUSG00000022026 UniProt Q6UX06 Q3UZZ4 RefSeq (mRNA) NM_006418 NM_001030294 NM_001351947 RefSeq (protein) NP_006409 NP_001025465 NP_001338876 Location (UCSC) Chr 13: 53.03 – 53.05 Mb Chr 14: 80.22 – 80.26 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Olfactomedin 4 is a protein that in humans is encoded by the OLFM4 gene.

Function

This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflamed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011].

Further reading

• Liu W, Chen L, Zhu J, Rodgers GP (2006). "The glycoprotein hGC-1 binds to cadherin and lectins". Exp. Cell Res. 312 (10): 1785–97. doi:10.1016/j.yexcr.2006.02.011. PMID 16566923.
• Liu W, Zhu J, Cao L, Rodgers GP (2007). "Expression of hGC-1 is correlated with differentiation of gastric carcinoma". Histopathology. 51 (2): 157–65. doi:10.1111/j.1365-2559.2007.02763.x. PMID 17650212. S2CID 27058889.
• Liu W, Liu Y, Zhu J, Wright E, Ding I, Rodgers GP (2008). "Reduced hGC-1 protein expression is associated with malignant progression of colon carcinoma". Clin. Cancer Res. 14 (4): 1041–9. doi:10.1158/1078-0432.CCR-07-4125. PMID 18281536.
• Conrotto P, Roesli C, Rybak J, Kischel P, Waltregny D, Neri D, Castronovo V (2008). "Identification of new accessible tumor antigens in human colon cancer by ex vivo protein biotinylation and comparative mass spectrometry analysis". Int. J. Cancer. 123 (12): 2856–64. doi:10.1002/ijc.23861. PMID 18798264. S2CID 19686678.
• van der Flier LG, Haegebarth A, Stange DE, van de Wetering M, Clevers H (2009). "OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells". Gastroenterology. 137 (1): 15–7. doi:10.1053/j.gastro.2009.05.035. PMID 19450592.
• Oue N, Sentani K, Noguchi T, Ohara S, Sakamoto N, Hayashi T, Anami K, Motoshita J, Ito M, Tanaka S, Yoshida K, Yasui W (2009). "Serum olfactomedin 4 (GW112, hGC-1) in combination with Reg IV is a highly sensitive biomarker for gastric cancer patients". Int. J. Cancer. 125 (10): 2383–92. doi:10.1002/ijc.24624. PMID 19670418.
• Liu W, Lee HW, Liu Y, Wang R, Rodgers GP (2010). "Olfactomedin 4 is a novel target gene of retinoic acids and 5-aza-2'-deoxycytidine involved in human myeloid leukemia cell growth, differentiation, and apoptosis". Blood. 116 (23): 4938–47. doi:10.1182/blood-2009-10-246439. PMC 3012588. PMID 20724538.
• Grover PK, Hardingham JE, Cummins AG (2010). "Stem cell marker olfactomedin 4: critical appraisal of its characteristics and role in tumorigenesis". Cancer Metastasis Rev. 29 (4): 761–75. doi:10.1007/s10555-010-9262-z. PMID 20878207. S2CID 35708557.
• Dassen H, Punyadeera C, Delvoux B, Schulkens I, Marchetti C, Kamps R, Klomp J, Dijcks F, de Goeij A, D'Hooghe T, Kyama C, Ederveen A, Dunselman G, Groothuis P, Romano A (2010). "Olfactomedin-4 regulation by estrogen in the human endometrium requires epidermal growth factor signaling". Am. J. Pathol. 177 (5): 2495–508. doi:10.2353/ajpath.2010.100026. PMC 2966806. PMID 21048224.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.