Oscar Marín

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Not to be confused with the American baseball player Oscar Marin.
Oscar Marín Parra
Born (1971-03-31) March 31, 1971 (age 53)}
Madrid
Alma materComplutense University of Madrid
Scientific career
FieldsNeuroscience
InstitutionsKing's College London

Oscar Marín Parra FMedSci FRS (born 31 March 1971) is a Spanish and British neuroscientist. He is married to neuroscientist Beatriz Rico.

Education[edit]

Oscar Marín was born in Madrid and received his undergraduate degree in Biology from Universidad Complutense de Madrid, and later his PhD in neuroscience. He then undertook postdoctoral training with M. Angela Nieto at the Instituto Cajal and John L. Rubenstein and Marc Tessier-Lavigne at the University of California in San Francisco.

Research and career[edit]

Before being appointed Professor of Neuroscience at King's College London in 2014, Marín started his career at the Instituto de Neurociencias in Alicante (Spain) between 2003 and 2014.

Marín is known for his discoveries concerning the specification.[1][2][3], migration[4][5][6] and wiring[7][8] of neurons in the cerebral cortex,[9] with special reference to the development of inhibitory interneurons.[10][11] These discoveries have provided a novel conceptual paradigm that illuminates current research on the origin of neurodevelopmental disorders such as autism and schizophrenia [12][13]

Awards and honours[edit]

In 2004, Marín received the European Young Investigator Award (EURYI) in its first round.[14] In 2011 he received the Rey Jaime I Award and in 2012 the FENS-EJN Young Investigator Award. In 2014 Marín received the Roger de Spoelberch Award for his work on the neurobiology of schizophrenia. In 2017 Marín received the Ramón y Cajal Medal from the Spanish Royal Academy of Sciences, and the Remedios Caro Almela Award in 2019.

Marín was elected a member of the European Molecular Biology Organization (EMBO) in 2010, and a member of the Academy of Medical Sciences in 2020. In 2022 he was elected a Fellow of the Royal Society.[15] Marín was a founding member of the European Research Council.

References[edit]

  1. ^ Sussel, L.; Marin, O.; Kimura, S.; Rubenstein, J.L. (August 1, 1999). "Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum". Development. 126 (15): 3359–3370. doi:10.1242/dev.126.15.3359. PMID 10393115 – via Silverchair.
  2. ^ Flames, Nuria; Pla, Ramón; Gelman, Diego M.; Rubenstein, John L. R.; Puelles, Luis; Marín, Oscar (September 5, 2007). "Delineation of Multiple Subpallial Progenitor Domains by the Combinatorial Expression of Transcriptional Codes". Journal of Neuroscience. 27 (36): 9682–9695. doi:10.1523/JNEUROSCI.2750-07.2007. PMC 4916652. PMID 17804629 – via Jneurosci.org.
  3. ^ Borrell, Víctor; Cárdenas, Adrián; Ciceri, Gabriele; Galcerán, Joan; Flames, Nuria; Pla, Ramón; Nóbrega-Pereira, Sandrina; García-Frigola, Cristina; Peregrín, Sandra; Zhao, Zhen; Ma, Le; Tessier-Lavigne, Marc; Marín, Oscar (2012). "Slit/Robo Signaling Modulates the Proliferation of Central Nervous System Progenitors". Neuron. 76 (2): 338–352. doi:10.1016/j.neuron.2012.08.003. PMC 4443924. PMID 23083737.
  4. ^ López-Bendito, Guillermina; Cautinat, Aline; Sánchez, Juan Antonio; Bielle, Franck; Flames, Nuria; Garratt, Alistair N.; Talmage, David A.; Role, Lorna W.; Charnay, Patrick; Marín, Oscar; Garel, Sonia (2006). "Tangential Neuronal Migration Controls Axon Guidance: A Role for Neuregulin-1 in Thalamocortical Axon Navigation". Cell. 125 (1): 127–142. doi:10.1016/j.cell.2006.01.042. PMC 2365888. PMID 16615895.
  5. ^ Sánchez-Alcañiz, Juan Antonio; Haege, Sammy; Mueller, Wiebke; Pla, Ramón; Mackay, Fabienne; Schulz, Stefan; López-Bendito, Guillermina; Stumm, Ralf; Marín, Oscar (January 13, 2011). "Cxcr7 Controls Neuronal Migration by Regulating Chemokine Responsiveness". Neuron. 69 (1): 77–90. doi:10.1016/j.neuron.2010.12.006. PMID 21220100. S2CID 11507206.
  6. ^ Villar-Cerviño, Verona; Molano-Mazón, Manuel; Catchpole, Timothy; Valdeolmillos, Miguel; Henkemeyer, Mark; Martínez, Luis M.; Borrell, Víctor; Marín, Oscar (February 6, 2013). "Contact Repulsion Controls the Dispersion and Final Distribution of Cajal-Retzius Cells". Neuron. 77 (3): 457–471. doi:10.1016/j.neuron.2012.11.023. PMC 3569744. PMID 23395373.
  7. ^ Fazzari, Pietro; Paternain, Ana V.; Valiente, Manuel; Pla, Ramón; Luján, Rafael; Lloyd, Kent; Lerma, Juan; Marín, Oscar; Rico, Beatriz (April 13, 2010). "Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling". Nature. 464 (7293): 1376–1380. Bibcode:2010Natur.464.1376F. doi:10.1038/nature08928. PMID 20393464. S2CID 4345605 – via Nature.com.
  8. ^ del Pino, Isabel; Brotons-Mas, Jorge R.; Marques-Smith, André; Marighetto, Aline; Frick, Andreas; Marín, Oscar; Rico, Beatriz (June 13, 2017). "Abnormal wiring of CCK+ basket cells disrupts spatial information coding". Nature Neuroscience. 20 (6): 784–792. doi:10.1038/nn.4544. PMC 5446788. PMID 28394324.
  9. ^ "Neurons dynamically switch identity in response to brain activity". The Guardian. September 17, 2015.
  10. ^ Marı́n, Oscar; Yaron, Avraham; Bagri, Anil; Tessier-Lavigne, Marc; Rubenstein, John L. R. (August 3, 2001). "Sorting of Striatal and Cortical Interneurons Regulated by Semaphorin-Neuropilin Interactions". Science. 293 (5531): 872–875. doi:10.1126/science.1061891. PMID 11486090. S2CID 14764907.
  11. ^ Mi, Da; Li, Zhen; Lim, Lynette; Li, Mingfeng; Moissidis, Monika; Yang, Yifei; Gao, Tianliuyun; Hu, Tim Xiaoming; Pratt, Thomas; Price, David J.; Sestan, Nenad; Marín, Oscar (April 6, 2018). "Early emergence of cortical interneuron diversity in the mouse embryo". Science. 360 (6384): 81–85. Bibcode:2018Sci...360...81M. doi:10.1126/science.aar6821. PMC 6195193. PMID 29472441.
  12. ^ Flames, Nuria; Long, Jason E.; Garratt, Alistair N.; Fischer, Tobias M.; Gassmann, Martin; Birchmeier, Carmen; Lai, Cary; Rubenstein, John L. R.; Marı́n, Oscar (October 14, 2004). "Short- and Long-Range Attraction of Cortical GABAergic Interneurons by Neuregulin-1". Neuron. 44 (2): 251–261. doi:10.1016/j.neuron.2004.09.028. PMID 15473965. S2CID 14576611.
  13. ^ Wong, Fong Kuan; Bercsenyi, Kinga; Sreenivasan, Varun; Portalés, Adrián; Fernández-Otero, Marian; Marín, Oscar (May 13, 2018). "Pyramidal cell regulation of interneuron survival sculpts cortical networks". Nature. 557 (7707): 668–673. Bibcode:2018Natur.557..668W. doi:10.1038/s41586-018-0139-6. PMC 6207348. PMID 29849154.
  14. ^ "2004 : European Science Foundation".
  15. ^ "'Changing small pieces of the cerebral cortex can generate superhero abilities': Óscar Marín, neuroscientist". 15 July 2022.
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