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PHF2

From Wikipedia, the free encyclopedia
PHF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPHF2, CENP-35, GRC5, JHDM1E, PHD finger protein 2, KDM7C
External IDsOMIM: 604351; MGI: 1338034; HomoloGene: 3934; GeneCards: PHF2; OMA:PHF2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005392
NM_024517

NM_011078

RefSeq (protein)

NP_005383

NP_035208

Location (UCSC)Chr 9: 93.58 – 93.68 MbChr 13: 48.96 – 49.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PHD finger protein 2 is a protein that in humans is encoded by the PHF2 gene.[5]

Function

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This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197724Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038025Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: PHD finger protein 2". Retrieved 2016-04-09.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.