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PKIG

From Wikipedia, the free encyclopedia

PKIG
Identifiers
AliasesPKIG, PKI-gamma, protein kinase (cAMP-dependent, catalytic) inhibitor gamma, cAMP-dependent protein kinase inhibitor gamma
External IDsOMIM: 604932; MGI: 1343086; HomoloGene: 5133; GeneCards: PKIG; OMA:PKIG - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_181805
NM_001281444
NM_001281445
NM_007066
NM_181804

RefSeq (protein)

NP_001268373
NP_001268374
NP_008997
NP_861520
NP_861521

Location (UCSC)Chr 20: 44.53 – 44.62 MbChr 2: 163.5 – 163.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

cAMP-dependent protein kinase inhibitor gamma is a protein that in humans is encoded by the PKIG gene.[5][6]

The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive PKA inhibitor, and is a predominant form of PKA inhibitors in various tissues. Three alternatively spliced transcript variants encoding the same protein have been reported.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168734Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035268Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zheng L, Yu L, Tu Q, Zhang M, He H, Chen W, Gao J, Yu J, Wu Q, Zhao S (Jan 2001). "Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA". Biochem J. 349 (Pt 2): 403–7. doi:10.1042/0264-6021:3490403. PMC 1221161. PMID 10880337.
  6. ^ a b "Entrez Gene: PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma".

Further reading

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